Tampere University of Technology

TUTCRIS Research Portal

Research group: Molecular Signaling Lab

Research unit: Research Group

Organisation profile

 

The Molecular Signaling Lab (MS Lab) lead by Adjunct professor/Research fellow Meenakshisundaram Kandhavelu focuses on understanding molecular signaling network communication. These networks play crucial roles in gene expression regulation and cell fate determination. By investigating molecular signaling pathways that contribute to cancer and other diseases, research in MS Lab is breaking new ground. Improper intra and/or extracellular signal transduction affects cells well-being and lead to various diseases. Specifically, we study the canonical and non-canonical signaling pathways activated by GPCRs at single cell level. For this, our group deploys interdisciplinary research knowledge such as cell and molecular experimental approach, single cell imaging, image processing, signal processing, computational models and bioinformatics

 

Latest research outputs

  1. Published

    In vitro anti-glioblastoma activity of L-valine derived boroxazolidones

    Viswanathan, A., Sebastianelli, G., Brown, K., Raunio, J., Sipilä, V., Yli-Harja, O., Candeias, N. R. & Kandhavelu, M., 5 Jul 2019, In : European Journal of Pharmacology. 854, p. 194-200 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  2. Published

    2-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)benzonitrile as novel inhibitor of receptor tyrosine kinase and PI3K/AKT/mTOR signaling pathway in glioblastoma

    Viswanathan, A., Kute, D., Musa, A., Mani, S. K., Sipilä, V., Emmert-Streib, F., Zubkov, F. I., Gurbanov, A. V., Yli-Harja, O. & Kandhavelu, M., 15 Mar 2019, In : European Journal of Medicinal Chemistry. 166, p. 291 - 303

    Research output: Contribution to journalArticleScientificpeer-review

  3. Published

    Alkylaminophenol induces G1/S phase cell cycle arrest in glioblastoma cells through p53 and cyclin-dependent kinase signaling pathway

    Doan, P., Musa, A., Candeias, N. R., Emmert-Streib, F., Yli-Harja, O. & Kandhavelu, M., 2019, In : FRONTIERS IN PHARMACOLOGY. 10, APR, 330.

    Research output: Contribution to journalArticleScientificpeer-review

Publications per year

No data available

ID: 10548573