Tampere University of Technology

TUTCRIS Research Portal

Research group: Molecular Signaling Lab

Research unit: Research Group

  1. 2019
  2. Published

    Battling Glioblastoma: A Novel Tyrosine Kinase Inhibitor with Multi-Dimensional Anti-Tumor Effect (Running Title: Cancer Cells Death Signalling Activation)

    Viswanathan, A., Musa, A., Murugesan, A., Vale, J. R., Afonso, C. A. M., Konda Mani, S., Yli-Harja, O., Candeias, N. R. & Kandhavelu, M., 12 Dec 2019, In : Cells. 8, 12, 18 p., 1624.

    Research output: Contribution to journalArticleScientificpeer-review

  3. Published

    Synthesis and preclinical validation of novel P2Y1 receptor ligands as a potent anti-prostate cancer agent

    Le, H. T. T., Rimpilainen, T., Konda Mani, S., Murugesan, A., Yli-Harja, O., Candeias, N. R. & Kandhavelu, M., 12 Dec 2019, In : Scientific Reports. 9, 18938.

    Research output: Contribution to journalArticleScientificpeer-review

  4. Published

    In vitro anti-glioblastoma activity of L-valine derived boroxazolidones

    Viswanathan, A., Sebastianelli, G., Brown, K., Raunio, J., Sipilä, V., Yli-Harja, O., Candeias, N. R. & Kandhavelu, M., 5 Jul 2019, In : European Journal of Pharmacology. 854, p. 194-200 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  5. Published

    2-(2-(2,4-dioxopentan-3-ylidene)hydrazineyl)benzonitrile as novel inhibitor of receptor tyrosine kinase and PI3K/AKT/mTOR signaling pathway in glioblastoma

    Viswanathan, A., Kute, D., Musa, A., Mani, S. K., Sipilä, V., Emmert-Streib, F., Zubkov, F. I., Gurbanov, A. V., Yli-Harja, O. & Kandhavelu, M., 15 Mar 2019, In : European Journal of Medicinal Chemistry. 166, p. 291 - 303

    Research output: Contribution to journalArticleScientificpeer-review

  6. Published

    Alkylaminophenol induces G1/S phase cell cycle arrest in glioblastoma cells through p53 and cyclin-dependent kinase signaling pathway

    Doan, P., Musa, A., Candeias, N. R., Emmert-Streib, F., Yli-Harja, O. & Kandhavelu, M., 2019, In : FRONTIERS IN PHARMACOLOGY. 10, APR, 330.

    Research output: Contribution to journalArticleScientificpeer-review

  7. 2018
  8. Published

    In vitro characterization of alkylaminophenols-induced cell death

    Doan, P., Anufrieva, O., Yli-Harja, O. & Kandhavelu, M., Feb 2018, In : European Journal of Pharmacology. 820, p. 229-234 6 p.

    Research output: Contribution to journalArticleScientificpeer-review

  9. Published

    GPR17 is a novel target for personalized medicine for glioblastoma

    Doan, P., Musa, A., Nguyen, T., Saravanan, K. M., Sipilä, V., Emmert-Streib, F., Yli-Harja, O. & Kandhavelu, M., 2018, The 4th Annual Finnish Symposium on Brain Tumors, FIBTRA: Vanajanlinna, Hämeenlinna, 29-30 November 2018.

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

  10. Published

    Identification of novel GPR17-agonists by structural bioinformatics and signaling activation

    Saravanan, KM., Palanivel, S., Yli-Harja, O. & Kandhavelu, M., 2018, In : International Journal of Biological Macromolecules. 106, p. 901-907

    Research output: Contribution to journalArticleScientificpeer-review

  11. 2017
  12. Published

    Quantification of Transcriptional Noise at Single Cell Single Molecule Level

    Anufrieva, O., Yli-Harja, O. & Kandhavelu, M., Dec 2017, In : EC Microbiology. 13, 2, p. 45-54

    Research output: Contribution to journalArticleProfessional

  13. Published

    Antibacterial and antitumor properties of alkylaminophenols derived from Petasis borono-Mannich multicomponent reaction

    Rafael Candeias, N., Rijo, P. & Kandhavelu, M., 2017.

    Research output: Other conference contributionPaper, poster or abstractScientific

  14. Published

    Base catalysed N-functionalisation of boroxazolidones

    J., R., Mannoja, J., Nguyen, T., N., A., N. M., K., Franzén, R. G., Kandhavelu, M. & Candeias, N. R., 2017, In : RSC Advances. 7, 33, p. 20620-20627 8 p.

    Research output: Contribution to journalArticleScientificpeer-review

  15. Published

    Image-based cell cycle analysis at single cell level

    Sipilä, V., Doan, P., Ruusuvuori, P., Yli-Harja, O. & Kandhavelu, M., 2017.

    Research output: Other conference contributionPaper, poster or abstractScientific

  16. Published

    Induction of cell cycle arrest and apoptosis of glioma cancer stem cells

    Doan, P., Sipilä, V., Yli-Harja, O., Rafael Candeias, N. & Kandhavelu, M., 2017.

    Research output: Other conference contributionPaper, poster or abstractScientific

  17. Published

    Investigation of novel long-chain diol derivatives as potential growth inhibitors of glioblastoma

    Zhurina, A., Viswanathan, A., Assoah, B., Paakkunainen, A., Yli-Harja, O., Rafael Candeias, N. & Kandhavelu, M., 2017.

    Research output: Other conference contributionPaper, poster or abstractScientific

  18. Published

    QSAR and Molecular Docking Analysis of synthetic compounds against Breast Cancer Targets

    Palanivel, S., Yli-Harja, O. & Kandhavelu, M., 2017.

    Research output: Other conference contributionPaper, poster or abstractScientific

  19. Published

    Synthesis of phenol-derivatives and biological screening for anticancer activity

    Karjalainen, A., Doan, P., Sandberg, O., Chandraseelan, J. G., Yli-Harja, O., R. Candeias, N. & Kandhavelu, M., 2017, In : Anti-Cancer Agents in Medicinal Chemistry. 17, 12, p. 1710-1720

    Research output: Contribution to journalArticleScientificpeer-review

  20. 2016
  21. Published

    Real-time observation of bacterial gene expression noise

    Anufrieva, O., Sala, A., Yli-Harja, O. & Kandhavelu, M., Jun 2016, In : Nano Communication Networks. 8, p. 68-75

    Research output: Contribution to journalArticleScientificpeer-review

  22. Published

    Synthesis and biological screening for cytotoxic activity of N-substituted indolines and morpholines

    Doan, P., Karjalainen, A., Chandraseelan, J. G., Sandberg, O., Yli-Harja, O., Rosholm, T., Franzén, R., R. Candeias, N. & Kandhavelu, M., May 2016, In : European Journal of Medicinal Chemistry. 120, p. 296-303

    Research output: Contribution to journalArticleScientificpeer-review

  23. Published

    Phase-dependent dynamics of the lac promoter under nutrient stress

    Viswanathan, A., Anufrieva, O., Sala, A., Yli-Harja, O. & Kandhavelu, M., 19 Apr 2016, In : Research in Microbiology. 167, 6, p. 451-461

    Research output: Contribution to journalArticleScientificpeer-review

  24. Published

    hGPR17 signaling cascade effects mitochondrial function

    Kandhavelu, M., 2016, In : The FEBS Journal. 283, S1

    Research output: Contribution to journalMeeting AbstractScientificpeer-review

  25. Published

    Regulation mitochondrial dysfunction function by human GPR17

    Kandhavelu, M., 2016.

    Research output: Other conference contributionPaper, poster or abstractScientific

  26. 2015
  27. Published

    Antimicrobial activity and molecular analysis of azoderivatives of β-diketones

    Viswanathan, A., Sala, A., Yli-Harja, O. & Kandhavelu, M., 23 Jan 2015, In : European Journal of Pharmaceutical Sciences. 66, p. 83-89 7 p.

    Research output: Contribution to journalArticleScientificpeer-review

  28. Published

    Development of efficient cell segmentation tool for microscope image

    Sandberg, O., Palanivel, S., Doan, P., Yli-Harja, O. & Kandhavelu, M., 2015.

    Research output: Other conference contributionPaper, poster or abstractScientific

  29. Published

    Investigation of small molecule effects in human embryonic kidney cell lines

    Palanivel, S., Yli-Harja, O. & Kandhavelu, M., 2015, p. 53.

    Research output: Other conference contributionPaper, poster or abstractScientific

  30. Published

    Novel small molecules are found to exhibit cytotoxic effect on osteosarcoma cells

    Karjalainen, A., Doan, P., Sandberg, O., Yli-Harja, O., Rafael Candeias, N. & Kandhavelu, M., 2015, p. 22.

    Research output: Other conference contributionPaper, poster or abstractScientific

  31. Published

    Origins of Transcriptional Transition: Balance between Upstream and Downstream Regulatory Gene Sequences

    Sala, A., Shoaib, M., Anufrieva, O., Mutharasu, G., Yli-Harja, O. & Kandhavelu, M., 2015, In : mBio. 6, 1, 9 p., e02182-14.

    Research output: Contribution to journalArticleScientificpeer-review

  32. Published

    Transcription closed and open complex dynamics studies reveal balance between genetic determinants and co-factors

    Sala, A., Shoaib, M., Anufrieva, O., Mutharasu, G., Hoque, R. J., Yli-Harja, O. & Kandhavelu, M., 2015, In : Physical Biology. 12, 3, 036003.

    Research output: Contribution to journalArticleScientificpeer-review

  33. 2014
  34. Published

    Analysis of Ca2+ and cAMP signaling regulated by GPR17 at single cell level.

    Palanivel, S., Yli-Harja, O. & Kandhavelu, M., 5 Dec 2014, p. 88. 1 p.

    Research output: Other conference contributionPaper, poster or abstractScientific

  35. Published

    Protein-protein interaction and coarse grained simulation study of Glioblastoma Multiforme reveals novel pathways of GPR17

    Mutharasu, G., Yli-harja, O. & Kandhavelu, M., 2014, In : TASK Quarterly. 18, 4, p. 321-325 5 p.

    Research output: Contribution to journalArticleScientificpeer-review

  36. 2013
  37. Published

    Study of the kinetics of transcription as a function of the cell growth phase

    Sala, A., Sanches Ribeiro, A. & Kandhavelu, M., 1 Jul 2013, FEBS journal. p. 570-570

    Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

ID: 10548573