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3D-Printed Whole Prostate Models with Tumor Hotspots Using Dual-Extruder Printer

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Details

Original languageEnglish
Title of host publication2019 41st Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherIEEE
Pages2867-2871
Number of pages5
ISBN (Electronic)978-1-5386-1311-5
ISBN (Print)978-1-5386-1312-2
DOIs
Publication statusPublished - 7 Oct 2019
Publication typeA4 Article in a conference publication
EventAnnual International Conference of the IEEE Engineering in Medicine and Biology Society -
Duration: 1 Jan 1900 → …

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
ISSN (Print)1557-170X
ISSN (Electronic)1558-4615

Conference

ConferenceAnnual International Conference of the IEEE Engineering in Medicine and Biology Society
Period1/01/00 → …

Abstract

3D printing has emerged as a popular technology in various biomedical applications. Physical models of anatomical structures concretize the digital representations and can be used for teaching and analysis. In this study we combine 3D histology with 3D printing, creating realistic physical models of tissues with hotspots of interest. As an example we use mouse prostates containing tumors. Surface meshes are created from binary masks of HE-stained serial sections of mouse prostates and manually annotated tumor areas. Sections are interpolated to expand sparse image stacks for smoother results. Fiji, Meshlab and Tinkercad are used for mesh creation and processing. Objects are printed with Prusa-based dual-extruder printer enabling different colors for tumors and the surrounding prostate tissue. Our 3D-printed mouse prostates appear realistic and tumors located at the edges of the organ are clearly visible. When transparent filament is used, the tumor hotspots are visible even when they are inside the prostate.

Keywords

  • Tumors, Solid modeling, Three-dimensional displays, Biological system modeling, Interpolation, Three-dimensional printing, Models of organ physiology, Organ modeling

Publication forum classification

Field of science, Statistics Finland