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96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)471-476
Number of pages6
JournalLetters in Drug Design and Discovery
Volume5
Publication statusPublished - 2008
Externally publishedYes
Publication typeA1 Journal article-refereed

Abstract

Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.

Keywords

  • Solubility, Surface tension, Ibuprofen, Indomethacin, High throughput screening (HTS), 96-well plate, HIGH-THROUGHPUT, AQUEOUS SOLUBILITY, DISCOVERY, PERMEABILITY, NEPHELOMETRY, EQUILIBRIUM, VALIDATION, ASSAY