96-Well Plate Surface Tension Measurements for Fast Determination of Drug Solubility
Research output: Contribution to journal › Article › Scientific › peer-review
Details
| Original language | English |
|---|---|
| Pages (from-to) | 471-476 |
| Number of pages | 6 |
| Journal | Letters in Drug Design and Discovery |
| Volume | 5 |
| Publication status | Published - 2008 |
| Externally published | Yes |
| Publication type | A1 Journal article-refereed |
Abstract
Surface tension based microtensiometric method for HTS (high throughput screening) of drug solubility properties is presented. Method was tested by determining physiologically relevant parameters on the solubility of ibuprofen and indomethacin. Linear correlation was found with equilibrium solubility. According to this study, microtensiometry is a promising technique for HTS solubility testing.
Keywords
- Solubility, Surface tension, Ibuprofen, Indomethacin, High throughput screening (HTS), 96-well plate, HIGH-THROUGHPUT, AQUEOUS SOLUBILITY, DISCOVERY, PERMEABILITY, NEPHELOMETRY, EQUILIBRIUM, VALIDATION, ASSAY