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99mTc-Sestamibi/123I Subtraction SPECT/CT in Parathyroid Scintigraphy: Is Additional Pinhole Imaging Useful?

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99mTc-Sestamibi/123I Subtraction SPECT/CT in Parathyroid Scintigraphy : Is Additional Pinhole Imaging Useful? / Tunninen, Virpi; Varjo, Pekka; Kauppinen, Tomi; Holm, Anu; Eskola, Hannu; Seppänen, Marko.

In: International Journal of Molecular Imaging, Vol. 2017, 2712018, 18.10.2017.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Tunninen, V, Varjo, P, Kauppinen, T, Holm, A, Eskola, H & Seppänen, M 2017, '99mTc-Sestamibi/123I Subtraction SPECT/CT in Parathyroid Scintigraphy: Is Additional Pinhole Imaging Useful?', International Journal of Molecular Imaging, vol. 2017, 2712018. https://doi.org/10.1155/2017/2712018

APA

Tunninen, V., Varjo, P., Kauppinen, T., Holm, A., Eskola, H., & Seppänen, M. (2017). 99mTc-Sestamibi/123I Subtraction SPECT/CT in Parathyroid Scintigraphy: Is Additional Pinhole Imaging Useful? International Journal of Molecular Imaging, 2017, [2712018]. https://doi.org/10.1155/2017/2712018

Vancouver

Tunninen V, Varjo P, Kauppinen T, Holm A, Eskola H, Seppänen M. 99mTc-Sestamibi/123I Subtraction SPECT/CT in Parathyroid Scintigraphy: Is Additional Pinhole Imaging Useful? International Journal of Molecular Imaging. 2017 Oct 18;2017. 2712018. https://doi.org/10.1155/2017/2712018

Author

Tunninen, Virpi ; Varjo, Pekka ; Kauppinen, Tomi ; Holm, Anu ; Eskola, Hannu ; Seppänen, Marko. / 99mTc-Sestamibi/123I Subtraction SPECT/CT in Parathyroid Scintigraphy : Is Additional Pinhole Imaging Useful?. In: International Journal of Molecular Imaging. 2017 ; Vol. 2017.

Bibtex - Download

@article{7f8ae291beda42d9b0503b2d3e1a398b,
title = "99mTc-Sestamibi/123I Subtraction SPECT/CT in Parathyroid Scintigraphy: Is Additional Pinhole Imaging Useful?",
abstract = "Objectives: This retrospective study evaluated whether the use of additional anterior 99mTc-sestamibi/123I pinhole imaging improves the outcome of 99mTc-sestamibi/123I subtraction SPECT/CT in parathyroid scintigraphy (PS).Materials and Methods: PS using simultaneous dual-isotope subtraction methods and an acquisition protocol combining SPECT/CT and planar pinhole imaging was performed for 175 patients with primary or secondary hyperparathyroidism. All patients who proceeded to surgery with complete postsurgery laboratory findings were included in this study (n = 94). SPECT/CT images alone and combined with pinhole images were evaluated.Results: There were 111 enlarged parathyroid glands of which 104 and 108 glands were correctly visualized by SPECT/CT (seven false positives) or SPECT/CT with pinhole (three false positives), respectively. Both sensitivity and specificity were higher with combined SPECT/CT with pinhole than with SPECT/CT alone (97{\%} versus 94{\%} and 99{\%} versus 98{\%}, resp., not significant). The false-positive rate was 6{\%} with SPECT/CT and decreased to 3{\%} using combined SPECT/CT with pinhole.Conclusion: 99mTc-sestamibi/123I subtraction SPECT/CT is a highly sensitive and specific protocol for PS. The use of additional anterior pinhole imaging increases both sensitivity and specificity of PS, although this increase is not statistically significant.",
keywords = "Journal Article",
author = "Virpi Tunninen and Pekka Varjo and Tomi Kauppinen and Anu Holm and Hannu Eskola and Marko Sepp{\"a}nen",
note = "EXT={"}Tunninen, Virpi{"} EXT={"}Sepp{\"a}nen, Marko{"}",
year = "2017",
month = "10",
day = "18",
doi = "10.1155/2017/2712018",
language = "English",
volume = "2017",
journal = "International Journal of Molecular Imaging",
issn = "2090-1712",
publisher = "Hindawi Publishing Corporation",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - 99mTc-Sestamibi/123I Subtraction SPECT/CT in Parathyroid Scintigraphy

T2 - Is Additional Pinhole Imaging Useful?

AU - Tunninen, Virpi

AU - Varjo, Pekka

AU - Kauppinen, Tomi

AU - Holm, Anu

AU - Eskola, Hannu

AU - Seppänen, Marko

N1 - EXT="Tunninen, Virpi" EXT="Seppänen, Marko"

PY - 2017/10/18

Y1 - 2017/10/18

N2 - Objectives: This retrospective study evaluated whether the use of additional anterior 99mTc-sestamibi/123I pinhole imaging improves the outcome of 99mTc-sestamibi/123I subtraction SPECT/CT in parathyroid scintigraphy (PS).Materials and Methods: PS using simultaneous dual-isotope subtraction methods and an acquisition protocol combining SPECT/CT and planar pinhole imaging was performed for 175 patients with primary or secondary hyperparathyroidism. All patients who proceeded to surgery with complete postsurgery laboratory findings were included in this study (n = 94). SPECT/CT images alone and combined with pinhole images were evaluated.Results: There were 111 enlarged parathyroid glands of which 104 and 108 glands were correctly visualized by SPECT/CT (seven false positives) or SPECT/CT with pinhole (three false positives), respectively. Both sensitivity and specificity were higher with combined SPECT/CT with pinhole than with SPECT/CT alone (97% versus 94% and 99% versus 98%, resp., not significant). The false-positive rate was 6% with SPECT/CT and decreased to 3% using combined SPECT/CT with pinhole.Conclusion: 99mTc-sestamibi/123I subtraction SPECT/CT is a highly sensitive and specific protocol for PS. The use of additional anterior pinhole imaging increases both sensitivity and specificity of PS, although this increase is not statistically significant.

AB - Objectives: This retrospective study evaluated whether the use of additional anterior 99mTc-sestamibi/123I pinhole imaging improves the outcome of 99mTc-sestamibi/123I subtraction SPECT/CT in parathyroid scintigraphy (PS).Materials and Methods: PS using simultaneous dual-isotope subtraction methods and an acquisition protocol combining SPECT/CT and planar pinhole imaging was performed for 175 patients with primary or secondary hyperparathyroidism. All patients who proceeded to surgery with complete postsurgery laboratory findings were included in this study (n = 94). SPECT/CT images alone and combined with pinhole images were evaluated.Results: There were 111 enlarged parathyroid glands of which 104 and 108 glands were correctly visualized by SPECT/CT (seven false positives) or SPECT/CT with pinhole (three false positives), respectively. Both sensitivity and specificity were higher with combined SPECT/CT with pinhole than with SPECT/CT alone (97% versus 94% and 99% versus 98%, resp., not significant). The false-positive rate was 6% with SPECT/CT and decreased to 3% using combined SPECT/CT with pinhole.Conclusion: 99mTc-sestamibi/123I subtraction SPECT/CT is a highly sensitive and specific protocol for PS. The use of additional anterior pinhole imaging increases both sensitivity and specificity of PS, although this increase is not statistically significant.

KW - Journal Article

U2 - 10.1155/2017/2712018

DO - 10.1155/2017/2712018

M3 - Article

VL - 2017

JO - International Journal of Molecular Imaging

JF - International Journal of Molecular Imaging

SN - 2090-1712

M1 - 2712018

ER -