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A BRCA1-interacting lncRNA regulates homologous recombination

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A BRCA1-interacting lncRNA regulates homologous recombination. / Sharma, Vivek; Khurana, Simran; Kubben, Nard; Abdelmohsen, Kotb; Oberdoerffer, Philipp; Gorospe, Myriam; Misteli, Tom.

In: EMBO REPORTS, Vol. 16, No. 11, 01.11.2015, p. 1520-1534.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Sharma, V, Khurana, S, Kubben, N, Abdelmohsen, K, Oberdoerffer, P, Gorospe, M & Misteli, T 2015, 'A BRCA1-interacting lncRNA regulates homologous recombination', EMBO REPORTS, vol. 16, no. 11, pp. 1520-1534. https://doi.org/10.15252/embr.201540437

APA

Sharma, V., Khurana, S., Kubben, N., Abdelmohsen, K., Oberdoerffer, P., Gorospe, M., & Misteli, T. (2015). A BRCA1-interacting lncRNA regulates homologous recombination. EMBO REPORTS, 16(11), 1520-1534. https://doi.org/10.15252/embr.201540437

Vancouver

Sharma V, Khurana S, Kubben N, Abdelmohsen K, Oberdoerffer P, Gorospe M et al. A BRCA1-interacting lncRNA regulates homologous recombination. EMBO REPORTS. 2015 Nov 1;16(11):1520-1534. https://doi.org/10.15252/embr.201540437

Author

Sharma, Vivek ; Khurana, Simran ; Kubben, Nard ; Abdelmohsen, Kotb ; Oberdoerffer, Philipp ; Gorospe, Myriam ; Misteli, Tom. / A BRCA1-interacting lncRNA regulates homologous recombination. In: EMBO REPORTS. 2015 ; Vol. 16, No. 11. pp. 1520-1534.

Bibtex - Download

@article{3c3cbf907a744d12a6ffaa9098ab0e48,
title = "A BRCA1-interacting lncRNA regulates homologous recombination",
abstract = "Long non-coding RNAs (lncRNAs) are important players in diverse biological processes. Upon DNA damage, cells activate a complex signaling cascade referred to as the DNA damage response (DDR). Using a microarray screen, we identify here a novel lncRNA, DDSR1 (DNA damage-sensitive RNA1), which is induced upon DNA damage. DDSR1 induction is triggered in an ATM-NF-κB pathway-dependent manner by several DNA double-strand break (DSB) agents. Loss of DDSR1 impairs cell proliferation and DDR signaling and reduces DNA repair capacity by homologous recombination (HR). The HR defect in the absence of DDSR1 is marked by aberrant accumulation of BRCA1 and RAP80 at DSB sites. In line with a role in regulating HR, DDSR1 interacts with BRCA1 and hnRNPUL1, an RNA-binding protein involved in DNA end resection. Our results suggest a role for the lncRNA DDSR1 in modulating DNA repair by HR.",
keywords = "BRCA1, hnRNPUL1, p53, RAP80, repair",
author = "Vivek Sharma and Simran Khurana and Nard Kubben and Kotb Abdelmohsen and Philipp Oberdoerffer and Myriam Gorospe and Tom Misteli",
year = "2015",
month = "11",
day = "1",
doi = "10.15252/embr.201540437",
language = "English",
volume = "16",
pages = "1520--1534",
journal = "EMBO REPORTS",
issn = "1469-221X",
publisher = "EMBO Press",
number = "11",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A BRCA1-interacting lncRNA regulates homologous recombination

AU - Sharma, Vivek

AU - Khurana, Simran

AU - Kubben, Nard

AU - Abdelmohsen, Kotb

AU - Oberdoerffer, Philipp

AU - Gorospe, Myriam

AU - Misteli, Tom

PY - 2015/11/1

Y1 - 2015/11/1

N2 - Long non-coding RNAs (lncRNAs) are important players in diverse biological processes. Upon DNA damage, cells activate a complex signaling cascade referred to as the DNA damage response (DDR). Using a microarray screen, we identify here a novel lncRNA, DDSR1 (DNA damage-sensitive RNA1), which is induced upon DNA damage. DDSR1 induction is triggered in an ATM-NF-κB pathway-dependent manner by several DNA double-strand break (DSB) agents. Loss of DDSR1 impairs cell proliferation and DDR signaling and reduces DNA repair capacity by homologous recombination (HR). The HR defect in the absence of DDSR1 is marked by aberrant accumulation of BRCA1 and RAP80 at DSB sites. In line with a role in regulating HR, DDSR1 interacts with BRCA1 and hnRNPUL1, an RNA-binding protein involved in DNA end resection. Our results suggest a role for the lncRNA DDSR1 in modulating DNA repair by HR.

AB - Long non-coding RNAs (lncRNAs) are important players in diverse biological processes. Upon DNA damage, cells activate a complex signaling cascade referred to as the DNA damage response (DDR). Using a microarray screen, we identify here a novel lncRNA, DDSR1 (DNA damage-sensitive RNA1), which is induced upon DNA damage. DDSR1 induction is triggered in an ATM-NF-κB pathway-dependent manner by several DNA double-strand break (DSB) agents. Loss of DDSR1 impairs cell proliferation and DDR signaling and reduces DNA repair capacity by homologous recombination (HR). The HR defect in the absence of DDSR1 is marked by aberrant accumulation of BRCA1 and RAP80 at DSB sites. In line with a role in regulating HR, DDSR1 interacts with BRCA1 and hnRNPUL1, an RNA-binding protein involved in DNA end resection. Our results suggest a role for the lncRNA DDSR1 in modulating DNA repair by HR.

KW - BRCA1

KW - hnRNPUL1

KW - p53

KW - RAP80

KW - repair

UR - http://www.scopus.com/inward/record.url?scp=84946489384&partnerID=8YFLogxK

U2 - 10.15252/embr.201540437

DO - 10.15252/embr.201540437

M3 - Article

VL - 16

SP - 1520

EP - 1534

JO - EMBO REPORTS

JF - EMBO REPORTS

SN - 1469-221X

IS - 11

ER -