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A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer

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A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer. / Schwartzman, Jacob; Mongoue-Tchokote, Solange; Gibbs, Angela; Gao, Lina; Corless, Christopher L.; Jin, Jennifer; Zarour, Luai; Higano, Celestia; True, Lawrence D.; Vessella, Robert L.; Wilmot, Beth; Bottomly, Daniel; McWeeney, Shannon K.; Bova, Steven G.; Partin, Alan W.; Mori, Motomi; Alumkal, Joshi J.

In: EPIGENETICS, Vol. 6, No. 10, 2011, p. 1248-1256.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Schwartzman, J, Mongoue-Tchokote, S, Gibbs, A, Gao, L, Corless, CL, Jin, J, Zarour, L, Higano, C, True, LD, Vessella, RL, Wilmot, B, Bottomly, D, McWeeney, SK, Bova, SG, Partin, AW, Mori, M & Alumkal, JJ 2011, 'A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer', EPIGENETICS, vol. 6, no. 10, pp. 1248-1256. https://doi.org/10.4161/epi.6.10.17727

APA

Schwartzman, J., Mongoue-Tchokote, S., Gibbs, A., Gao, L., Corless, C. L., Jin, J., ... Alumkal, J. J. (2011). A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer. EPIGENETICS, 6(10), 1248-1256. https://doi.org/10.4161/epi.6.10.17727

Vancouver

Schwartzman J, Mongoue-Tchokote S, Gibbs A, Gao L, Corless CL, Jin J et al. A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer. EPIGENETICS. 2011;6(10):1248-1256. https://doi.org/10.4161/epi.6.10.17727

Author

Schwartzman, Jacob ; Mongoue-Tchokote, Solange ; Gibbs, Angela ; Gao, Lina ; Corless, Christopher L. ; Jin, Jennifer ; Zarour, Luai ; Higano, Celestia ; True, Lawrence D. ; Vessella, Robert L. ; Wilmot, Beth ; Bottomly, Daniel ; McWeeney, Shannon K. ; Bova, Steven G. ; Partin, Alan W. ; Mori, Motomi ; Alumkal, Joshi J. / A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer. In: EPIGENETICS. 2011 ; Vol. 6, No. 10. pp. 1248-1256.

Bibtex - Download

@article{845d4035c9984d29b078f1df5051161d,
title = "A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer",
abstract = "DNA methylation of promoter regions is a common event in prostate cancer, one of the most common cancers in men worldwide. Because prior reports demonstrating that DNA methylation is important in prostate cancer studied a limited number of genes, we systematically quantified the DNA methylation status of 1,505 CpG dinucleotides for 807 genes in 78 paraffin-embedded prostate cancer samples and three normal prostate samples. The ERG gene, commonly repressed in prostate cells in the absence of an oncogenic fusion to the TMPRSS2 gene, was one of the most commonly methylated genes, occurring in 74{\%} of prostate cancer specimens. In an independent group of patient samples, we confirmed that ERG DNA methylation was common, occurring in 57{\%} of specimens, and cancer-specific. The ERG promoter is marked by repressive chromatin marks mediated by polycomb proteins in both normal prostate cells and prostate cancer cells, which may explain ERG's predisposition to DNA methylation and the fact that tumors with ERG DNA methylation were more methylated, in general. These results demonstrate that bead arrays offer a high-throughput method to discover novel genes with promoter DNA methylation such as ERG, whose measurement may improve our ability to more accurately detect prostate cancer.",
keywords = "Biomarker, DNA methylation, ERG, Polycomb, Prostate cancer",
author = "Jacob Schwartzman and Solange Mongoue-Tchokote and Angela Gibbs and Lina Gao and Corless, {Christopher L.} and Jennifer Jin and Luai Zarour and Celestia Higano and True, {Lawrence D.} and Vessella, {Robert L.} and Beth Wilmot and Daniel Bottomly and McWeeney, {Shannon K.} and Bova, {Steven G.} and Partin, {Alan W.} and Motomi Mori and Alumkal, {Joshi J.}",
year = "2011",
doi = "10.4161/epi.6.10.17727",
language = "English",
volume = "6",
pages = "1248--1256",
journal = "EPIGENETICS",
issn = "1559-2294",
publisher = "Taylor & Francis",
number = "10",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - A DNA methylation microarray-based study identifies ERG as a gene commonly methylated in prostate cancer

AU - Schwartzman, Jacob

AU - Mongoue-Tchokote, Solange

AU - Gibbs, Angela

AU - Gao, Lina

AU - Corless, Christopher L.

AU - Jin, Jennifer

AU - Zarour, Luai

AU - Higano, Celestia

AU - True, Lawrence D.

AU - Vessella, Robert L.

AU - Wilmot, Beth

AU - Bottomly, Daniel

AU - McWeeney, Shannon K.

AU - Bova, Steven G.

AU - Partin, Alan W.

AU - Mori, Motomi

AU - Alumkal, Joshi J.

PY - 2011

Y1 - 2011

N2 - DNA methylation of promoter regions is a common event in prostate cancer, one of the most common cancers in men worldwide. Because prior reports demonstrating that DNA methylation is important in prostate cancer studied a limited number of genes, we systematically quantified the DNA methylation status of 1,505 CpG dinucleotides for 807 genes in 78 paraffin-embedded prostate cancer samples and three normal prostate samples. The ERG gene, commonly repressed in prostate cells in the absence of an oncogenic fusion to the TMPRSS2 gene, was one of the most commonly methylated genes, occurring in 74% of prostate cancer specimens. In an independent group of patient samples, we confirmed that ERG DNA methylation was common, occurring in 57% of specimens, and cancer-specific. The ERG promoter is marked by repressive chromatin marks mediated by polycomb proteins in both normal prostate cells and prostate cancer cells, which may explain ERG's predisposition to DNA methylation and the fact that tumors with ERG DNA methylation were more methylated, in general. These results demonstrate that bead arrays offer a high-throughput method to discover novel genes with promoter DNA methylation such as ERG, whose measurement may improve our ability to more accurately detect prostate cancer.

AB - DNA methylation of promoter regions is a common event in prostate cancer, one of the most common cancers in men worldwide. Because prior reports demonstrating that DNA methylation is important in prostate cancer studied a limited number of genes, we systematically quantified the DNA methylation status of 1,505 CpG dinucleotides for 807 genes in 78 paraffin-embedded prostate cancer samples and three normal prostate samples. The ERG gene, commonly repressed in prostate cells in the absence of an oncogenic fusion to the TMPRSS2 gene, was one of the most commonly methylated genes, occurring in 74% of prostate cancer specimens. In an independent group of patient samples, we confirmed that ERG DNA methylation was common, occurring in 57% of specimens, and cancer-specific. The ERG promoter is marked by repressive chromatin marks mediated by polycomb proteins in both normal prostate cells and prostate cancer cells, which may explain ERG's predisposition to DNA methylation and the fact that tumors with ERG DNA methylation were more methylated, in general. These results demonstrate that bead arrays offer a high-throughput method to discover novel genes with promoter DNA methylation such as ERG, whose measurement may improve our ability to more accurately detect prostate cancer.

KW - Biomarker

KW - DNA methylation

KW - ERG

KW - Polycomb

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=80053458910&partnerID=8YFLogxK

U2 - 10.4161/epi.6.10.17727

DO - 10.4161/epi.6.10.17727

M3 - Article

VL - 6

SP - 1248

EP - 1256

JO - EPIGENETICS

JF - EPIGENETICS

SN - 1559-2294

IS - 10

ER -