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Aerobic Fitness Does Not Modify the Effect of FTO Variation on Body Composition Traits

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Original languageEnglish
Article numbere51635
JournalPLoS ONE
Issue number12
Publication statusPublished - 17 Dec 2012
Publication typeA1 Journal article-refereed


Purpose: Poor physical fitness and obesity are risk factors for all cause morbidity and mortality. We aimed to clarify whether common genetic variants of key energy intake determinants in leptin (LEP), leptin receptor (LEPR), and fat mass and obesity-associated (FTO) are associated with aerobic and neuromuscular performance, and whether aerobic fitness can alter the effect of these genotypes on body composition. Methods: 846 healthy Finnish males of Caucasian origin were genotyped for FTO (rs8050136), LEP (rs7799039) and LEPR (rs8179183 and rs1137101) single nucleotide polymorphisms (SNPs), and studied for associations with maximal oxygen consumption, body fat percent, serum leptin levels, waist circumference and maximal force of leg extensor muscles. Results: Genotype AA of the FTO SNP rs8050136 associated with higher BMI and greater waist circumference compared to the genotype CC. In general linear model, no significant interaction for FTO genotype-relative VO2max (mL·kg-1·min-1) or FTO genotype-absolute VO2max (L·min-1) on BMI or waist circumference was found. Main effects of aerobic performance on body composition traits were significant (p