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Altered synaptic signaling due to β-amyloid interference in astrocytes: A modeling study

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Details

Original languageEnglish
Title of host publicationEMBEC and NBC 2017 - Joint Conference of the European Medical and Biological Engineering Conference EMBEC 2017 and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2017
PublisherSpringer Verlag
Pages679-682
Number of pages4
ISBN (Print)9789811051210
DOIs
Publication statusPublished - 2018
Publication typeA4 Article in a conference publication
EventJoint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC) -
Duration: 1 Jan 1900 → …

Publication series

NameIFMBE Proceedings
Volume65
ISSN (Print)1680-0737

Conference

ConferenceJoint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC)
Period1/01/00 → …

Abstract

Astrocytes are active participants in brain physiology and a known target of pathological processes of several diseases. Using a mathematical model of a tripartite synapse, we investigated the effects of astrocyte intracellular β-amyloid 1-42 fragments on astrocyte Ca2+ signaling and synaptic signal transmission. Our results show that with this model, β-amyloid interference of astrocyte Ca2+ signaling can considerably alter signal transmission at the synapse, and even silence postsynaptic firing. We conclude that when disturbing astrocyte Ca2+ signaling, β-amyloid fragments can potentially contribute to changes in synaptic signaling.

ASJC Scopus subject areas

Keywords

  • Astrocytes, Biophysical modeling, Tripartite synapses, β-amyloid

Publication forum classification

Field of science, Statistics Finland