Altered synaptic signaling due to β-amyloid interference in astrocytes: A modeling study
Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › Scientific › peer-review
Details
| Original language | English |
|---|---|
| Title of host publication | EMBEC and NBC 2017 - Joint Conference of the European Medical and Biological Engineering Conference EMBEC 2017 and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics, NBC 2017 |
| Publisher | Springer Verlag |
| Pages | 679-682 |
| Number of pages | 4 |
| ISBN (Print) | 9789811051210 |
| DOIs | |
| Publication status | Published - 2018 |
| Publication type | A4 Article in a conference publication |
| Event | Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC) - Duration: 1 Jan 1900 → … |
Publication series
| Name | IFMBE Proceedings |
|---|---|
| Volume | 65 |
| ISSN (Print) | 1680-0737 |
Conference
| Conference | Joint Conference of the European Medical and Biological Engineering Conference (EMBEC) and the Nordic-Baltic Conference on Biomedical Engineering and Medical Physics (NBC) |
|---|---|
| Period | 1/01/00 → … |
Abstract
Astrocytes are active participants in brain physiology and a known target of pathological processes of several diseases. Using a mathematical model of a tripartite synapse, we investigated the effects of astrocyte intracellular β-amyloid 1-42 fragments on astrocyte Ca2+ signaling and synaptic signal transmission. Our results show that with this model, β-amyloid interference of astrocyte Ca2+ signaling can considerably alter signal transmission at the synapse, and even silence postsynaptic firing. We conclude that when disturbing astrocyte Ca2+ signaling, β-amyloid fragments can potentially contribute to changes in synaptic signaling.
ASJC Scopus subject areas
Keywords
- Astrocytes, Biophysical modeling, Tripartite synapses, β-amyloid