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Analysis of apoptosis-related genes in patients with clinically isolated syndrome and their association with conversion to multiple sclerosis

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalJOURNAL OF NEUROIMMUNOLOGY
Volume280
DOIs
Publication statusPublished - 15 Mar 2015
Publication typeA1 Journal article-refereed

Abstract

To analyse whether the expression of apoptotic transcripts is associated with the conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS). Eleven candidate transcripts belonging to the death receptor pathway, BCL-2, the inflammasome complex and NF-ΚB family were studied in the nonconverting and converting CIS patients during the four-year follow-up period. Conversion to MS was associated with marked variability in the expression of proapoptotic genes that were linked to TGF-B1 gene levels. The predominant expression of proapoptotic genes in patients with CIS suggests an increased potential to undergo apoptosis with the goal of terminating immune responses and regulating immune system homeostasis.

Keywords

  • Apoptosis, BCL-2, Biomarkers, Clinically isolated syndrome, Multiple sclerosis