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Analysis of Light Propagation on Physiological Properties of Neurons for Nanoscale Optogenetics

Research output: Contribution to journalArticleScientificpeer-review

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Analysis of Light Propagation on Physiological Properties of Neurons for Nanoscale Optogenetics. / Wirdatmadja, Stefanus; Johari, Pedram; Desai, Aesha; Bae, Yongho; Stachowiak, Ewa K.; Stachowiak, Michal K.; Jornet, Josep M.; Balasubramaniam, Sasitharan.

In: IEEE Transactions on Neural Systems and Rehabilitation Engineering, Vol. 27, No. 2, 01.02.2019, p. 108-117.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Wirdatmadja, S, Johari, P, Desai, A, Bae, Y, Stachowiak, EK, Stachowiak, MK, Jornet, JM & Balasubramaniam, S 2019, 'Analysis of Light Propagation on Physiological Properties of Neurons for Nanoscale Optogenetics', IEEE Transactions on Neural Systems and Rehabilitation Engineering, vol. 27, no. 2, pp. 108-117. https://doi.org/10.1109/TNSRE.2019.2891271

APA

Wirdatmadja, S., Johari, P., Desai, A., Bae, Y., Stachowiak, E. K., Stachowiak, M. K., ... Balasubramaniam, S. (2019). Analysis of Light Propagation on Physiological Properties of Neurons for Nanoscale Optogenetics. IEEE Transactions on Neural Systems and Rehabilitation Engineering, 27(2), 108-117. https://doi.org/10.1109/TNSRE.2019.2891271

Vancouver

Wirdatmadja S, Johari P, Desai A, Bae Y, Stachowiak EK, Stachowiak MK et al. Analysis of Light Propagation on Physiological Properties of Neurons for Nanoscale Optogenetics. IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2019 Feb 1;27(2):108-117. https://doi.org/10.1109/TNSRE.2019.2891271

Author

Wirdatmadja, Stefanus ; Johari, Pedram ; Desai, Aesha ; Bae, Yongho ; Stachowiak, Ewa K. ; Stachowiak, Michal K. ; Jornet, Josep M. ; Balasubramaniam, Sasitharan. / Analysis of Light Propagation on Physiological Properties of Neurons for Nanoscale Optogenetics. In: IEEE Transactions on Neural Systems and Rehabilitation Engineering. 2019 ; Vol. 27, No. 2. pp. 108-117.

Bibtex - Download

@article{14b708519ba84dff972a32a6c9c83816,
title = "Analysis of Light Propagation on Physiological Properties of Neurons for Nanoscale Optogenetics",
abstract = "Miniaturization of implantable devices is an important challenge for future brain-computer interface applications, and in particular for achieving precise neuron stimulation. For stimulation that utilizes light, i.e., optogenetics, the light propagation behavior and interaction at the nanoscale with elements within the neuron is an important factor that needs to be considered when designing the device. This paper analyzes the effect of light behavior for a single neuron stimulation and focuses on the impact from different cell shapes. Based on the Mie scattering theory, the paper analyzes how the shape of the soma and the nucleus contributes to the focusing effect resulting in an intensity increase, which ensures that neurons can assist in transferring light through the tissue toward the target cells. At the same time, this intensity increase can in turn also stimulate neighboring cells leading to interference within the neural circuits. This paper also analyzes the ideal placements of the device with respect to the angle and position within the cortex that can enable axonal biophoton communications, which can contain light within the cell to avoid the interference.",
keywords = "biological tissues, bio-optics, brain, cellular biophysics, light propagation, Mie scattering, neurophysiology, prosthetics, physiological properties, nanoscale optogenetics, implantable devices, future brain-computer interface applications, precise neuron stimulation, light propagation behavior, light behavior, single neuron stimulation, Mie scattering theory, focusing effect, intensity increase, target cells, cell shapes, miniaturization, Neurons, Shape, Biological tissues, Brain modeling, Nanoscale devices, Nano communications, optogenetics, geometrical optics analysis",
author = "Stefanus Wirdatmadja and Pedram Johari and Aesha Desai and Yongho Bae and Stachowiak, {Ewa K.} and Stachowiak, {Michal K.} and Jornet, {Josep M.} and Sasitharan Balasubramaniam",
year = "2019",
month = "2",
day = "1",
doi = "10.1109/TNSRE.2019.2891271",
language = "English",
volume = "27",
pages = "108--117",
journal = "IEEE Transactions on Neural Systems and Rehabilitation Engineering",
issn = "1534-4320",
publisher = "Institute of Electrical and Electronics Engineers",
number = "2",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Analysis of Light Propagation on Physiological Properties of Neurons for Nanoscale Optogenetics

AU - Wirdatmadja, Stefanus

AU - Johari, Pedram

AU - Desai, Aesha

AU - Bae, Yongho

AU - Stachowiak, Ewa K.

AU - Stachowiak, Michal K.

AU - Jornet, Josep M.

AU - Balasubramaniam, Sasitharan

PY - 2019/2/1

Y1 - 2019/2/1

N2 - Miniaturization of implantable devices is an important challenge for future brain-computer interface applications, and in particular for achieving precise neuron stimulation. For stimulation that utilizes light, i.e., optogenetics, the light propagation behavior and interaction at the nanoscale with elements within the neuron is an important factor that needs to be considered when designing the device. This paper analyzes the effect of light behavior for a single neuron stimulation and focuses on the impact from different cell shapes. Based on the Mie scattering theory, the paper analyzes how the shape of the soma and the nucleus contributes to the focusing effect resulting in an intensity increase, which ensures that neurons can assist in transferring light through the tissue toward the target cells. At the same time, this intensity increase can in turn also stimulate neighboring cells leading to interference within the neural circuits. This paper also analyzes the ideal placements of the device with respect to the angle and position within the cortex that can enable axonal biophoton communications, which can contain light within the cell to avoid the interference.

AB - Miniaturization of implantable devices is an important challenge for future brain-computer interface applications, and in particular for achieving precise neuron stimulation. For stimulation that utilizes light, i.e., optogenetics, the light propagation behavior and interaction at the nanoscale with elements within the neuron is an important factor that needs to be considered when designing the device. This paper analyzes the effect of light behavior for a single neuron stimulation and focuses on the impact from different cell shapes. Based on the Mie scattering theory, the paper analyzes how the shape of the soma and the nucleus contributes to the focusing effect resulting in an intensity increase, which ensures that neurons can assist in transferring light through the tissue toward the target cells. At the same time, this intensity increase can in turn also stimulate neighboring cells leading to interference within the neural circuits. This paper also analyzes the ideal placements of the device with respect to the angle and position within the cortex that can enable axonal biophoton communications, which can contain light within the cell to avoid the interference.

KW - biological tissues

KW - bio-optics

KW - brain

KW - cellular biophysics

KW - light propagation

KW - Mie scattering

KW - neurophysiology

KW - prosthetics

KW - physiological properties

KW - nanoscale optogenetics

KW - implantable devices

KW - future brain-computer interface applications

KW - precise neuron stimulation

KW - light propagation behavior

KW - light behavior

KW - single neuron stimulation

KW - Mie scattering theory

KW - focusing effect

KW - intensity increase

KW - target cells

KW - cell shapes

KW - miniaturization

KW - Neurons

KW - Shape

KW - Biological tissues

KW - Brain modeling

KW - Nanoscale devices

KW - Nano communications

KW - optogenetics

KW - geometrical optics analysis

U2 - 10.1109/TNSRE.2019.2891271

DO - 10.1109/TNSRE.2019.2891271

M3 - Article

VL - 27

SP - 108

EP - 117

JO - IEEE Transactions on Neural Systems and Rehabilitation Engineering

JF - IEEE Transactions on Neural Systems and Rehabilitation Engineering

SN - 1534-4320

IS - 2

ER -