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AROS has a context-dependent effect on SIRT1

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Details

Original languageEnglish
Pages (from-to)1523-1528
Number of pages6
JournalFEBS Letters
Volume588
Issue number9
DOIs
Publication statusPublished - 2 May 2014
Publication typeA1 Journal article-refereed

Abstract

The modulation of protein deacetylase SIRT1 has a vast therapeutic potential in treatment of several aging-associated diseases. Active regulator of SIRT1 (AROS) is a small endogenous protein which was originally reported to activate SIRT1 through a direct interaction in cancer cells. We show that the interaction between the two proteins is weak and does not alter the activity of SIRT1 in non-cancerous human cells. The results of different in vitro SIRT1 activity assays disclosed AROS as an inhibitor of SIRT1. The functional relationship between AROS and SIRT1 proved to be dependent on the biological context and experimental setting.

Keywords

  • AROS, p53, Protein-protein interaction, SIRT1, Sirtuin