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Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)579-587
Number of pages9
JournalCirculation: Cardiovascular Genetics
Volume6
Issue number6
DOIs
Publication statusPublished - Dec 2013
Publication typeA1 Journal article-refereed

Abstract

Background-Macrophage (MF) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MF trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. Methods and Results-The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (-2.9-fold; P

Keywords

  • Atherosclerosis, Gene expression, Immunohistochemistry, Macrophages, Myocytes, Smooth muscle, Whole genome association analysis