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Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)

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Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS). / Oksala, Niku; Pärssinen, Jenita; Seppälä, Ilkka; Raitoharju, Emma; Ivana, Kholova; Hernesniemi, Jussi; Lyytikäinen, Leo Pekka; Levula, Mari; Mäkelä, Kari Matti; Sioris, Thanos; Kähönen, Mika; Laaksonen, Reijo; Hytönen, Vesa; Lehtimäki, Terho.

In: Circulation: Cardiovascular Genetics, Vol. 6, No. 6, 12.2013, p. 579-587.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Oksala, N, Pärssinen, J, Seppälä, I, Raitoharju, E, Ivana, K, Hernesniemi, J, Lyytikäinen, LP, Levula, M, Mäkelä, KM, Sioris, T, Kähönen, M, Laaksonen, R, Hytönen, V & Lehtimäki, T 2013, 'Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)', Circulation: Cardiovascular Genetics, vol. 6, no. 6, pp. 579-587. https://doi.org/10.1161/CIRCGENETICS.113.000141

APA

Oksala, N., Pärssinen, J., Seppälä, I., Raitoharju, E., Ivana, K., Hernesniemi, J., ... Lehtimäki, T. (2013). Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS). Circulation: Cardiovascular Genetics, 6(6), 579-587. https://doi.org/10.1161/CIRCGENETICS.113.000141

Vancouver

Author

Oksala, Niku ; Pärssinen, Jenita ; Seppälä, Ilkka ; Raitoharju, Emma ; Ivana, Kholova ; Hernesniemi, Jussi ; Lyytikäinen, Leo Pekka ; Levula, Mari ; Mäkelä, Kari Matti ; Sioris, Thanos ; Kähönen, Mika ; Laaksonen, Reijo ; Hytönen, Vesa ; Lehtimäki, Terho. / Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS). In: Circulation: Cardiovascular Genetics. 2013 ; Vol. 6, No. 6. pp. 579-587.

Bibtex - Download

@article{c5e4f22cf9f446c193812d77002bfc5d,
title = "Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)",
abstract = "Background-Macrophage (MF) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MF trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. Methods and Results-The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (-2.9-fold; P",
keywords = "Atherosclerosis, Gene expression, Immunohistochemistry, Macrophages, Myocytes, Smooth muscle, Whole genome association analysis",
author = "Niku Oksala and Jenita P{\"a}rssinen and Ilkka Sepp{\"a}l{\"a} and Emma Raitoharju and Kholova Ivana and Jussi Hernesniemi and Lyytik{\"a}inen, {Leo Pekka} and Mari Levula and M{\"a}kel{\"a}, {Kari Matti} and Thanos Sioris and Mika K{\"a}h{\"o}nen and Reijo Laaksonen and Vesa Hyt{\"o}nen and Terho Lehtim{\"a}ki",
year = "2013",
month = "12",
doi = "10.1161/CIRCGENETICS.113.000141",
language = "English",
volume = "6",
pages = "579--587",
journal = "Circulation: Cardiovascular Genetics",
issn = "1942-325X",
publisher = "American Heart Association",
number = "6",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Association of neuroimmune guidance cue netrin-1 and its chemorepulsive receptor UNC5B with atherosclerotic plaque expression signatures and stability in human(s) Tampere Vascular Study (TVS)

AU - Oksala, Niku

AU - Pärssinen, Jenita

AU - Seppälä, Ilkka

AU - Raitoharju, Emma

AU - Ivana, Kholova

AU - Hernesniemi, Jussi

AU - Lyytikäinen, Leo Pekka

AU - Levula, Mari

AU - Mäkelä, Kari Matti

AU - Sioris, Thanos

AU - Kähönen, Mika

AU - Laaksonen, Reijo

AU - Hytönen, Vesa

AU - Lehtimäki, Terho

PY - 2013/12

Y1 - 2013/12

N2 - Background-Macrophage (MF) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MF trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. Methods and Results-The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (-2.9-fold; P

AB - Background-Macrophage (MF) infiltration and smooth muscle cell (SMC) proliferation are hallmarks of atherosclerosis and unstable plaques. Neuroimmune guidance cue 1 (netrin-1 [NTN1]) plays a critical role controlling MF trafficking and SMC activation. Characterization of expression of NTN1 and its receptors and their association with plaque stability in human(s) is lacking. Methods and Results-The expression of NTN1 and its receptors did not differ in either whole blood or circulating monocytes from patients with coronary artery disease (n=55) compared with healthy controls (n=45). However, NTN1 was downregulated (-2.9-fold; P

KW - Atherosclerosis

KW - Gene expression

KW - Immunohistochemistry

KW - Macrophages

KW - Myocytes

KW - Smooth muscle

KW - Whole genome association analysis

UR - http://www.scopus.com/inward/record.url?scp=84892423180&partnerID=8YFLogxK

U2 - 10.1161/CIRCGENETICS.113.000141

DO - 10.1161/CIRCGENETICS.113.000141

M3 - Article

VL - 6

SP - 579

EP - 587

JO - Circulation: Cardiovascular Genetics

JF - Circulation: Cardiovascular Genetics

SN - 1942-325X

IS - 6

ER -