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Autoimmunity-related immunological serum markers and survival in a tertiary care cohort of adult patients with epilepsy

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Details

Original languageEnglish
Pages (from-to)1675-1679
Number of pages5
JournalEPILEPSY RESEARCH
Volume108
Issue number9
DOIs
Publication statusPublished - 1 Nov 2014
Publication typeA1 Journal article-refereed

Abstract

We evaluated mortality in relation to a panel of autoimmunity-related immunological serum markers in adult patients with epilepsy (PWE), seen in 1996-1997 at the Department of Neurology, Oulu University Hospital in Finland. Blood samples were drawn from 968 volunteers, and baseline measurements included serum immunoglobulins (IgG, IgA, and IgM), and the following antibodies: anticardiolipin, antinuclear, antimitochondrial, antigliadin (IgA and IgG classes), IgA tissue transglutaminase, and IgA endomysial. Hazard ratios (HR) for all-cause mortality in PWE with abnormal immunological markers relative to 413 patients with normal findings were evaluated with adjustment for confounders during a follow-up of nine years. Borderline statistically significant associations were found only for elevated IgA (HR 2.09, 95% CI 0.99-4.42) and for having two or more abnormal antibody titers (HR 1.58, 95% CI 0.98-2.56). The findings of this exploratory study suggested that elevated serum IgA might be associated with excess mortality in PWE.

ASJC Scopus subject areas

Keywords

  • Autoantibodies, Endomysial antibodies, Epilepsy, Immunoglobulin A, Mortality