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Bi-directional cell-pericellular matrix interactions direct stem cell fate

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Bi-directional cell-pericellular matrix interactions direct stem cell fate. / Ferreira, Silvia A.; Motwani, Meghna S.; Faull, Peter A.; Seymour, Alexis J.; Yu, Tracy T.L.; Enayati, Marjan; Taheem, Dheraj K.; Salzlechner, Christoph; Haghighi, Tabasom; Kania, Ewa M.; Oommen, Oommen P.; Ahmed, Tarek; Loaiza, Sandra; Parzych, Katarzyna; Dazzi, Francesco; Varghese, Oommen P.; Festy, Frederic; Grigoriadis, Agamemnon E.; Auner, Holger W.; Snijders, Ambrosius P.; Bozec, Laurent; Gentleman, Eileen.

In: Nature Communications, Vol. 9, No. 1, 4049, 12.2018.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Ferreira, SA, Motwani, MS, Faull, PA, Seymour, AJ, Yu, TTL, Enayati, M, Taheem, DK, Salzlechner, C, Haghighi, T, Kania, EM, Oommen, OP, Ahmed, T, Loaiza, S, Parzych, K, Dazzi, F, Varghese, OP, Festy, F, Grigoriadis, AE, Auner, HW, Snijders, AP, Bozec, L & Gentleman, E 2018, 'Bi-directional cell-pericellular matrix interactions direct stem cell fate', Nature Communications, vol. 9, no. 1, 4049. https://doi.org/10.1038/s41467-018-06183-4

APA

Ferreira, S. A., Motwani, M. S., Faull, P. A., Seymour, A. J., Yu, T. T. L., Enayati, M., ... Gentleman, E. (2018). Bi-directional cell-pericellular matrix interactions direct stem cell fate. Nature Communications, 9(1), [4049]. https://doi.org/10.1038/s41467-018-06183-4

Vancouver

Ferreira SA, Motwani MS, Faull PA, Seymour AJ, Yu TTL, Enayati M et al. Bi-directional cell-pericellular matrix interactions direct stem cell fate. Nature Communications. 2018 Dec;9(1). 4049. https://doi.org/10.1038/s41467-018-06183-4

Author

Ferreira, Silvia A. ; Motwani, Meghna S. ; Faull, Peter A. ; Seymour, Alexis J. ; Yu, Tracy T.L. ; Enayati, Marjan ; Taheem, Dheraj K. ; Salzlechner, Christoph ; Haghighi, Tabasom ; Kania, Ewa M. ; Oommen, Oommen P. ; Ahmed, Tarek ; Loaiza, Sandra ; Parzych, Katarzyna ; Dazzi, Francesco ; Varghese, Oommen P. ; Festy, Frederic ; Grigoriadis, Agamemnon E. ; Auner, Holger W. ; Snijders, Ambrosius P. ; Bozec, Laurent ; Gentleman, Eileen. / Bi-directional cell-pericellular matrix interactions direct stem cell fate. In: Nature Communications. 2018 ; Vol. 9, No. 1.

Bibtex - Download

@article{63ea835deb054ca694c73e4953a47324,
title = "Bi-directional cell-pericellular matrix interactions direct stem cell fate",
abstract = "Modifiable hydrogels have revealed tremendous insight into how physical characteristics of cells’ 3D environment drive stem cell lineage specification. However, in native tissues, cells do not passively receive signals from their niche. Instead they actively probe and modify their pericellular space to suit their needs, yet the dynamics of cells’ reciprocal interactions with their pericellular environment when encapsulated within hydrogels remains relatively unexplored. Here, we show that human bone marrow stromal cells (hMSC) encapsulated within hyaluronic acid-based hydrogels modify their surroundings by synthesizing, secreting and arranging proteins pericellularly or by degrading the hydrogel. hMSC’s interactions with this local environment have a role in regulating hMSC fate, with a secreted proteinaceous pericellular matrix associated with adipogenesis, and degradation with osteogenesis. Our observations suggest that hMSC participate in a bi-directional interplay between the properties of their 3D milieu and their own secreted pericellular matrix, and that this combination of interactions drives fate.",
author = "Ferreira, {Silvia A.} and Motwani, {Meghna S.} and Faull, {Peter A.} and Seymour, {Alexis J.} and Yu, {Tracy T.L.} and Marjan Enayati and Taheem, {Dheraj K.} and Christoph Salzlechner and Tabasom Haghighi and Kania, {Ewa M.} and Oommen, {Oommen P.} and Tarek Ahmed and Sandra Loaiza and Katarzyna Parzych and Francesco Dazzi and Varghese, {Oommen P.} and Frederic Festy and Grigoriadis, {Agamemnon E.} and Auner, {Holger W.} and Snijders, {Ambrosius P.} and Laurent Bozec and Eileen Gentleman",
year = "2018",
month = "12",
doi = "10.1038/s41467-018-06183-4",
language = "English",
volume = "9",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Bi-directional cell-pericellular matrix interactions direct stem cell fate

AU - Ferreira, Silvia A.

AU - Motwani, Meghna S.

AU - Faull, Peter A.

AU - Seymour, Alexis J.

AU - Yu, Tracy T.L.

AU - Enayati, Marjan

AU - Taheem, Dheraj K.

AU - Salzlechner, Christoph

AU - Haghighi, Tabasom

AU - Kania, Ewa M.

AU - Oommen, Oommen P.

AU - Ahmed, Tarek

AU - Loaiza, Sandra

AU - Parzych, Katarzyna

AU - Dazzi, Francesco

AU - Varghese, Oommen P.

AU - Festy, Frederic

AU - Grigoriadis, Agamemnon E.

AU - Auner, Holger W.

AU - Snijders, Ambrosius P.

AU - Bozec, Laurent

AU - Gentleman, Eileen

PY - 2018/12

Y1 - 2018/12

N2 - Modifiable hydrogels have revealed tremendous insight into how physical characteristics of cells’ 3D environment drive stem cell lineage specification. However, in native tissues, cells do not passively receive signals from their niche. Instead they actively probe and modify their pericellular space to suit their needs, yet the dynamics of cells’ reciprocal interactions with their pericellular environment when encapsulated within hydrogels remains relatively unexplored. Here, we show that human bone marrow stromal cells (hMSC) encapsulated within hyaluronic acid-based hydrogels modify their surroundings by synthesizing, secreting and arranging proteins pericellularly or by degrading the hydrogel. hMSC’s interactions with this local environment have a role in regulating hMSC fate, with a secreted proteinaceous pericellular matrix associated with adipogenesis, and degradation with osteogenesis. Our observations suggest that hMSC participate in a bi-directional interplay between the properties of their 3D milieu and their own secreted pericellular matrix, and that this combination of interactions drives fate.

AB - Modifiable hydrogels have revealed tremendous insight into how physical characteristics of cells’ 3D environment drive stem cell lineage specification. However, in native tissues, cells do not passively receive signals from their niche. Instead they actively probe and modify their pericellular space to suit their needs, yet the dynamics of cells’ reciprocal interactions with their pericellular environment when encapsulated within hydrogels remains relatively unexplored. Here, we show that human bone marrow stromal cells (hMSC) encapsulated within hyaluronic acid-based hydrogels modify their surroundings by synthesizing, secreting and arranging proteins pericellularly or by degrading the hydrogel. hMSC’s interactions with this local environment have a role in regulating hMSC fate, with a secreted proteinaceous pericellular matrix associated with adipogenesis, and degradation with osteogenesis. Our observations suggest that hMSC participate in a bi-directional interplay between the properties of their 3D milieu and their own secreted pericellular matrix, and that this combination of interactions drives fate.

U2 - 10.1038/s41467-018-06183-4

DO - 10.1038/s41467-018-06183-4

M3 - Article

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 4049

ER -