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Biodegradable biliary stents have a different effect than covered metal stents on the expression of proteins associated with tissue healing in benign biliary strictures

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Biodegradable biliary stents have a different effect than covered metal stents on the expression of proteins associated with tissue healing in benign biliary strictures. / Siiki, Antti; Jesenofsky, Ralf; Löhr, Matthias; Nordback, Isto; Kellomäki, Minna; Gröhn, Heidi; Mikkonen, Joonas; Sand, Juhani; Laukkarinen, Johanna.

In: Scandinavian Journal of Gastroenterology, Vol. 51, No. 7, 2016, p. 880-885.

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Siiki, A, Jesenofsky, R, Löhr, M, Nordback, I, Kellomäki, M, Gröhn, H, Mikkonen, J, Sand, J & Laukkarinen, J 2016, 'Biodegradable biliary stents have a different effect than covered metal stents on the expression of proteins associated with tissue healing in benign biliary strictures', Scandinavian Journal of Gastroenterology, vol. 51, no. 7, pp. 880-885. https://doi.org/10.3109/00365521.2016.1156153

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Siiki, Antti ; Jesenofsky, Ralf ; Löhr, Matthias ; Nordback, Isto ; Kellomäki, Minna ; Gröhn, Heidi ; Mikkonen, Joonas ; Sand, Juhani ; Laukkarinen, Johanna. / Biodegradable biliary stents have a different effect than covered metal stents on the expression of proteins associated with tissue healing in benign biliary strictures. In: Scandinavian Journal of Gastroenterology. 2016 ; Vol. 51, No. 7. pp. 880-885.

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@article{5c3125bc6af145bf8f14b927ced2d122,
title = "Biodegradable biliary stents have a different effect than covered metal stents on the expression of proteins associated with tissue healing in benign biliary strictures",
abstract = "Background Benign biliary strictures (BBS) are primarily treated endoscopically with covered self-expandable metal stents (CSEMS). Biodegradable biliary stents (BDBS) may be the future of endoscopic therapy of BBS. The aim was to assess the expression of proteins related to tissue healing in BBS compared with the intact bile duct (BD), and to study the protein expression after therapy with CSEMS or BDBS. Methods Pigs with ischemic BBS were endoscopically treated either with BDBS or CSEMS. Samples were harvested from pigs with intact BD (n = 5), untreated BBS (n = 5), and after six months of therapy with BDBS (n = 4) or CSEMS (n = 5) with subsequent histologic analysis. Two-dimensional electrophoresis with protein identification was performed to evaluate protein expression patterns. Results In BBS, the expression of galectin-2 and annexin-A4 decreased, compared to intact BD. Treatment with biodegradable stents normalized galectin-2 level; with CSEMS therapy it remained low. Transgelin expression of intact BD and BBS remained low after BDBS treatment but increased after CSEMS therapy. Histologic analysis did not show unwanted foreign body reaction or hyperplasia in the BD in either group. Conclusions The expression of proteins related to tissue healing in BBS is different after treatment with biodegradable stents and CSEMS. Treatment with biodegradable stents may bring protein expression towards what is seen in intact BD. BDBS seem to have a good biocompatibility.",
keywords = "Biliary, bioabsorbable, biodegradable, ERCP (endoscopic retrograde cholangio-pancreatography), stent, stricture",
author = "Antti Siiki and Ralf Jesenofsky and Matthias L{\"o}hr and Isto Nordback and Minna Kellom{\"a}ki and Heidi Gr{\"o}hn and Joonas Mikkonen and Juhani Sand and Johanna Laukkarinen",
year = "2016",
doi = "10.3109/00365521.2016.1156153",
language = "English",
volume = "51",
pages = "880--885",
journal = "Scandinavian Journal of Gastroenterology",
issn = "0036-5521",
publisher = "Taylor & Francis",
number = "7",

}

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TY - JOUR

T1 - Biodegradable biliary stents have a different effect than covered metal stents on the expression of proteins associated with tissue healing in benign biliary strictures

AU - Siiki, Antti

AU - Jesenofsky, Ralf

AU - Löhr, Matthias

AU - Nordback, Isto

AU - Kellomäki, Minna

AU - Gröhn, Heidi

AU - Mikkonen, Joonas

AU - Sand, Juhani

AU - Laukkarinen, Johanna

PY - 2016

Y1 - 2016

N2 - Background Benign biliary strictures (BBS) are primarily treated endoscopically with covered self-expandable metal stents (CSEMS). Biodegradable biliary stents (BDBS) may be the future of endoscopic therapy of BBS. The aim was to assess the expression of proteins related to tissue healing in BBS compared with the intact bile duct (BD), and to study the protein expression after therapy with CSEMS or BDBS. Methods Pigs with ischemic BBS were endoscopically treated either with BDBS or CSEMS. Samples were harvested from pigs with intact BD (n = 5), untreated BBS (n = 5), and after six months of therapy with BDBS (n = 4) or CSEMS (n = 5) with subsequent histologic analysis. Two-dimensional electrophoresis with protein identification was performed to evaluate protein expression patterns. Results In BBS, the expression of galectin-2 and annexin-A4 decreased, compared to intact BD. Treatment with biodegradable stents normalized galectin-2 level; with CSEMS therapy it remained low. Transgelin expression of intact BD and BBS remained low after BDBS treatment but increased after CSEMS therapy. Histologic analysis did not show unwanted foreign body reaction or hyperplasia in the BD in either group. Conclusions The expression of proteins related to tissue healing in BBS is different after treatment with biodegradable stents and CSEMS. Treatment with biodegradable stents may bring protein expression towards what is seen in intact BD. BDBS seem to have a good biocompatibility.

AB - Background Benign biliary strictures (BBS) are primarily treated endoscopically with covered self-expandable metal stents (CSEMS). Biodegradable biliary stents (BDBS) may be the future of endoscopic therapy of BBS. The aim was to assess the expression of proteins related to tissue healing in BBS compared with the intact bile duct (BD), and to study the protein expression after therapy with CSEMS or BDBS. Methods Pigs with ischemic BBS were endoscopically treated either with BDBS or CSEMS. Samples were harvested from pigs with intact BD (n = 5), untreated BBS (n = 5), and after six months of therapy with BDBS (n = 4) or CSEMS (n = 5) with subsequent histologic analysis. Two-dimensional electrophoresis with protein identification was performed to evaluate protein expression patterns. Results In BBS, the expression of galectin-2 and annexin-A4 decreased, compared to intact BD. Treatment with biodegradable stents normalized galectin-2 level; with CSEMS therapy it remained low. Transgelin expression of intact BD and BBS remained low after BDBS treatment but increased after CSEMS therapy. Histologic analysis did not show unwanted foreign body reaction or hyperplasia in the BD in either group. Conclusions The expression of proteins related to tissue healing in BBS is different after treatment with biodegradable stents and CSEMS. Treatment with biodegradable stents may bring protein expression towards what is seen in intact BD. BDBS seem to have a good biocompatibility.

KW - Biliary

KW - bioabsorbable

KW - biodegradable

KW - ERCP (endoscopic retrograde cholangio-pancreatography)

KW - stent

KW - stricture

U2 - 10.3109/00365521.2016.1156153

DO - 10.3109/00365521.2016.1156153

M3 - Article

VL - 51

SP - 880

EP - 885

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

SN - 0036-5521

IS - 7

ER -