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Bioluminescent whole-cell reporter gene assays as screening tools in the identification of antimicrobial natural product extracts

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Bioluminescent whole-cell reporter gene assays as screening tools in the identification of antimicrobial natural product extracts. / Nybond, Susanna; Karp, Matti; Yrjönen, Teijo; Tammela, Päivi.

In: Journal of Microbiological Methods, Vol. 114, 01.07.2015, p. 54-56.

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Nybond, Susanna ; Karp, Matti ; Yrjönen, Teijo ; Tammela, Päivi. / Bioluminescent whole-cell reporter gene assays as screening tools in the identification of antimicrobial natural product extracts. In: Journal of Microbiological Methods. 2015 ; Vol. 114. pp. 54-56.

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@article{56d356c12d6942b393833c125565ebd5,
title = "Bioluminescent whole-cell reporter gene assays as screening tools in the identification of antimicrobial natural product extracts",
abstract = "We describe novel tools, bioluminescent whole-cell reporter gene assays, for facilitating the use of natural products in antimicrobial drug discovery. As proof-of-concept, a plant extract library was screened and follow-up experiments were carried out. Primary results can be obtained in 2-4. h with high sensitivity, leading to significant improvements of the process.",
keywords = "Antibacterial, Bioluminescence, Cell-based assay, Escherichia coli, Natural products, Screening",
author = "Susanna Nybond and Matti Karp and Teijo Yrj{\"o}nen and P{\"a}ivi Tammela",
year = "2015",
month = "7",
day = "1",
doi = "10.1016/j.mimet.2015.04.014",
language = "English",
volume = "114",
pages = "54--56",
journal = "Journal of Microbiological Methods",
issn = "0167-7012",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Bioluminescent whole-cell reporter gene assays as screening tools in the identification of antimicrobial natural product extracts

AU - Nybond, Susanna

AU - Karp, Matti

AU - Yrjönen, Teijo

AU - Tammela, Päivi

PY - 2015/7/1

Y1 - 2015/7/1

N2 - We describe novel tools, bioluminescent whole-cell reporter gene assays, for facilitating the use of natural products in antimicrobial drug discovery. As proof-of-concept, a plant extract library was screened and follow-up experiments were carried out. Primary results can be obtained in 2-4. h with high sensitivity, leading to significant improvements of the process.

AB - We describe novel tools, bioluminescent whole-cell reporter gene assays, for facilitating the use of natural products in antimicrobial drug discovery. As proof-of-concept, a plant extract library was screened and follow-up experiments were carried out. Primary results can be obtained in 2-4. h with high sensitivity, leading to significant improvements of the process.

KW - Antibacterial

KW - Bioluminescence

KW - Cell-based assay

KW - Escherichia coli

KW - Natural products

KW - Screening

UR - http://www.scopus.com/inward/record.url?scp=84928920094&partnerID=8YFLogxK

U2 - 10.1016/j.mimet.2015.04.014

DO - 10.1016/j.mimet.2015.04.014

M3 - Article

VL - 114

SP - 54

EP - 56

JO - Journal of Microbiological Methods

JF - Journal of Microbiological Methods

SN - 0167-7012

ER -