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Biomimetic hemo-compatible surfaces of polyurethane by grafting copolymer brushes of poly(ethylene glycol) and poly(phosphorylcholine methacrylate)

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Biomimetic hemo-compatible surfaces of polyurethane by grafting copolymer brushes of poly(ethylene glycol) and poly(phosphorylcholine methacrylate). / Yang, Dazhi; Feng, Yakai; Behl, Marc; Lendlein, Andreas; Zhao, Haiyang; Khan, Musammir; Guo, Jintang.

Multifunctional Polymer-Based Materials. Vol. 1403 2012. p. 171-176.

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Harvard

Yang, D, Feng, Y, Behl, M, Lendlein, A, Zhao, H, Khan, M & Guo, J 2012, Biomimetic hemo-compatible surfaces of polyurethane by grafting copolymer brushes of poly(ethylene glycol) and poly(phosphorylcholine methacrylate). in Multifunctional Polymer-Based Materials. vol. 1403, pp. 171-176, 2011 MRS Fall Meeting, Boston, MA, United States, 28/11/11. https://doi.org/10.1557/opl.2012.702

APA

Yang, D., Feng, Y., Behl, M., Lendlein, A., Zhao, H., Khan, M., & Guo, J. (2012). Biomimetic hemo-compatible surfaces of polyurethane by grafting copolymer brushes of poly(ethylene glycol) and poly(phosphorylcholine methacrylate). In Multifunctional Polymer-Based Materials (Vol. 1403, pp. 171-176) https://doi.org/10.1557/opl.2012.702

Vancouver

Yang D, Feng Y, Behl M, Lendlein A, Zhao H, Khan M et al. Biomimetic hemo-compatible surfaces of polyurethane by grafting copolymer brushes of poly(ethylene glycol) and poly(phosphorylcholine methacrylate). In Multifunctional Polymer-Based Materials. Vol. 1403. 2012. p. 171-176 https://doi.org/10.1557/opl.2012.702

Author

Yang, Dazhi ; Feng, Yakai ; Behl, Marc ; Lendlein, Andreas ; Zhao, Haiyang ; Khan, Musammir ; Guo, Jintang. / Biomimetic hemo-compatible surfaces of polyurethane by grafting copolymer brushes of poly(ethylene glycol) and poly(phosphorylcholine methacrylate). Multifunctional Polymer-Based Materials. Vol. 1403 2012. pp. 171-176

Bibtex - Download

@inproceedings{fe272f3b7f984f97a626d97cb5220d2a,
title = "Biomimetic hemo-compatible surfaces of polyurethane by grafting copolymer brushes of poly(ethylene glycol) and poly(phosphorylcholine methacrylate)",
abstract = "Polyurethanes (PU) have been widely used as biomaterial in recent years, while thrombus may still occur when contacting with blood especially for extended period of time. Poly(ethylene glycol) (PEG) and phosphorylcholine (PC)-based polymers are commonly employed for surface modification to create protein repellent surfaces. PC-based polymers have been investigated as biomimetic materials because PC is the major component in the outer layer of cell membranes. In this study, the biomimetic copolymer brush of PEG-b-poly(2-methacryloyloxyethyl phosphorylcholine) on PU surfaces was synthesized via atom transfer radical polymerization (ATRP) with a surface initiator. The flexible PEG chain was 200 g·mol -1, while the poly(2-methacryloyloxyethyl phosphorylcholine) (poly(MPC)) chain length was controlled by the ratio of monomer to sacrificial initiator in solution. The topology of the modified surfaces was characterized by the phase image of atomic force microscopy (AFM) to study the synergy effect between PEG chains and poly(MPC) chains. The unmodified and modified surfaces were characterized by Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), water contact angle and platelet adhesion. The results demonstrated that efficient grafting of PEG-b-poly(MPC) brushes on the surfaces was achieved. The PU surfaces modified with PEG and phosphorylcholine zwitterionic brushes showed effective resistance to platelet adhesion and high hemocompatibility in vitro. These PEG and PC-grafted PU materials might be potentially applied in blood-contacting materials or devices due to their good mechanical and hemocompatible properties.",
author = "Dazhi Yang and Yakai Feng and Marc Behl and Andreas Lendlein and Haiyang Zhao and Musammir Khan and Jintang Guo",
year = "2012",
doi = "10.1557/opl.2012.702",
language = "English",
isbn = "9781605113807",
volume = "1403",
pages = "171--176",
booktitle = "Multifunctional Polymer-Based Materials",

}

RIS (suitable for import to EndNote) - Download

TY - GEN

T1 - Biomimetic hemo-compatible surfaces of polyurethane by grafting copolymer brushes of poly(ethylene glycol) and poly(phosphorylcholine methacrylate)

AU - Yang, Dazhi

AU - Feng, Yakai

AU - Behl, Marc

AU - Lendlein, Andreas

AU - Zhao, Haiyang

AU - Khan, Musammir

AU - Guo, Jintang

PY - 2012

Y1 - 2012

N2 - Polyurethanes (PU) have been widely used as biomaterial in recent years, while thrombus may still occur when contacting with blood especially for extended period of time. Poly(ethylene glycol) (PEG) and phosphorylcholine (PC)-based polymers are commonly employed for surface modification to create protein repellent surfaces. PC-based polymers have been investigated as biomimetic materials because PC is the major component in the outer layer of cell membranes. In this study, the biomimetic copolymer brush of PEG-b-poly(2-methacryloyloxyethyl phosphorylcholine) on PU surfaces was synthesized via atom transfer radical polymerization (ATRP) with a surface initiator. The flexible PEG chain was 200 g·mol -1, while the poly(2-methacryloyloxyethyl phosphorylcholine) (poly(MPC)) chain length was controlled by the ratio of monomer to sacrificial initiator in solution. The topology of the modified surfaces was characterized by the phase image of atomic force microscopy (AFM) to study the synergy effect between PEG chains and poly(MPC) chains. The unmodified and modified surfaces were characterized by Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), water contact angle and platelet adhesion. The results demonstrated that efficient grafting of PEG-b-poly(MPC) brushes on the surfaces was achieved. The PU surfaces modified with PEG and phosphorylcholine zwitterionic brushes showed effective resistance to platelet adhesion and high hemocompatibility in vitro. These PEG and PC-grafted PU materials might be potentially applied in blood-contacting materials or devices due to their good mechanical and hemocompatible properties.

AB - Polyurethanes (PU) have been widely used as biomaterial in recent years, while thrombus may still occur when contacting with blood especially for extended period of time. Poly(ethylene glycol) (PEG) and phosphorylcholine (PC)-based polymers are commonly employed for surface modification to create protein repellent surfaces. PC-based polymers have been investigated as biomimetic materials because PC is the major component in the outer layer of cell membranes. In this study, the biomimetic copolymer brush of PEG-b-poly(2-methacryloyloxyethyl phosphorylcholine) on PU surfaces was synthesized via atom transfer radical polymerization (ATRP) with a surface initiator. The flexible PEG chain was 200 g·mol -1, while the poly(2-methacryloyloxyethyl phosphorylcholine) (poly(MPC)) chain length was controlled by the ratio of monomer to sacrificial initiator in solution. The topology of the modified surfaces was characterized by the phase image of atomic force microscopy (AFM) to study the synergy effect between PEG chains and poly(MPC) chains. The unmodified and modified surfaces were characterized by Fourier transform infrared (FTIR), X-ray photoelectron spectroscopy (XPS), water contact angle and platelet adhesion. The results demonstrated that efficient grafting of PEG-b-poly(MPC) brushes on the surfaces was achieved. The PU surfaces modified with PEG and phosphorylcholine zwitterionic brushes showed effective resistance to platelet adhesion and high hemocompatibility in vitro. These PEG and PC-grafted PU materials might be potentially applied in blood-contacting materials or devices due to their good mechanical and hemocompatible properties.

UR - http://www.scopus.com/inward/record.url?scp=84865010271&partnerID=8YFLogxK

U2 - 10.1557/opl.2012.702

DO - 10.1557/opl.2012.702

M3 - Conference contribution

SN - 9781605113807

VL - 1403

SP - 171

EP - 176

BT - Multifunctional Polymer-Based Materials

ER -