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Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes

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Bobbing of Oxysterols : Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes. / Kulig, Waldemar; Mikkolainen, Heikki; Olżyńska, Agnieszka; Jurkiewicz, Piotr; Cwiklik, Lukasz; Hof, Martin; Vattulainen, Ilpo; Jungwirth, Pavel; Rog, Tomasz.

In: Journal of Physical Chemistry Letters, Vol. 9, No. 5, 01.03.2018, p. 1118-1123.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Kulig, W, Mikkolainen, H, Olżyńska, A, Jurkiewicz, P, Cwiklik, L, Hof, M, Vattulainen, I, Jungwirth, P & Rog, T 2018, 'Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes', Journal of Physical Chemistry Letters, vol. 9, no. 5, pp. 1118-1123. https://doi.org/10.1021/acs.jpclett.8b00211

APA

Kulig, W., Mikkolainen, H., Olżyńska, A., Jurkiewicz, P., Cwiklik, L., Hof, M., ... Rog, T. (2018). Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes. Journal of Physical Chemistry Letters, 9(5), 1118-1123. https://doi.org/10.1021/acs.jpclett.8b00211

Vancouver

Kulig W, Mikkolainen H, Olżyńska A, Jurkiewicz P, Cwiklik L, Hof M et al. Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes. Journal of Physical Chemistry Letters. 2018 Mar 1;9(5):1118-1123. https://doi.org/10.1021/acs.jpclett.8b00211

Author

Kulig, Waldemar ; Mikkolainen, Heikki ; Olżyńska, Agnieszka ; Jurkiewicz, Piotr ; Cwiklik, Lukasz ; Hof, Martin ; Vattulainen, Ilpo ; Jungwirth, Pavel ; Rog, Tomasz. / Bobbing of Oxysterols : Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes. In: Journal of Physical Chemistry Letters. 2018 ; Vol. 9, No. 5. pp. 1118-1123.

Bibtex - Download

@article{2b4b47de3bd24d55a7a2be272f219f7f,
title = "Bobbing of Oxysterols: Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes",
abstract = "Translocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action.",
author = "Waldemar Kulig and Heikki Mikkolainen and Agnieszka Olżyńska and Piotr Jurkiewicz and Lukasz Cwiklik and Martin Hof and Ilpo Vattulainen and Pavel Jungwirth and Tomasz Rog",
note = "INT=fys,{"}Mikkolainen, Heikki{"} EXT={"}Cwiklik, Lukasz{"}",
year = "2018",
month = "3",
day = "1",
doi = "10.1021/acs.jpclett.8b00211",
language = "English",
volume = "9",
pages = "1118--1123",
journal = "Journal of Physical Chemistry Letters",
issn = "1948-7185",
publisher = "American Chemical Society",
number = "5",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Bobbing of Oxysterols

T2 - Molecular Mechanism for Translocation of Tail-Oxidized Sterols through Biological Membranes

AU - Kulig, Waldemar

AU - Mikkolainen, Heikki

AU - Olżyńska, Agnieszka

AU - Jurkiewicz, Piotr

AU - Cwiklik, Lukasz

AU - Hof, Martin

AU - Vattulainen, Ilpo

AU - Jungwirth, Pavel

AU - Rog, Tomasz

N1 - INT=fys,"Mikkolainen, Heikki" EXT="Cwiklik, Lukasz"

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Translocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action.

AB - Translocation of sterols between cellular membrane leaflets is of key importance in membrane organization, dynamics, and signaling. We present a novel translocation mechanism that differs in a unique manner from the established ones. The bobbing mechanism identified here is demonstrated for tail-oxidized sterols, but is expected to be viable for any molecule containing two polar centers at the opposite sides of the molecule. The mechanism renders translocation across a lipid membrane possible without a change in molecular orientation. For tail-oxidized sterols, the bobbing mechanism provides an exceptionally facile means to translocate these signaling molecules across membrane structures and may thus represent an important pathway in the course of their biological action.

U2 - 10.1021/acs.jpclett.8b00211

DO - 10.1021/acs.jpclett.8b00211

M3 - Article

VL - 9

SP - 1118

EP - 1123

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

SN - 1948-7185

IS - 5

ER -