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Chromatographic studies of n-Propyl Propionate: Adsorption equilibrium, modelling and uncertainties determination

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Original languageEnglish
Pages (from-to)371-382
Number of pages12
JournalComputers and Chemical Engineering
Publication statusPublished - 2 Nov 2018
Publication typeA1 Journal article-refereed


The n-Propyl Propionate (ProPro) is a compound that has several possible industrial applications. However, the current production route of this component presents several problems, such as the downstream purification. In this way, chromatographic separation could be an alternative solution to the downstream purification. In this work experimental studies of the ProPro reaction system separation in a chromatographic fixed bed unit packed with Amberlyst 46 were performed. The adsorption equilibrium isotherms and the corresponding Langmuir model parameters were determined. A phenomenological model to represent the process was developed and validated through the experimental data. Meanwhile, it is proposed the characterization of the uncertainties of all steps and its extension to the model prediction, which allowed to estimate the model parameters with a reduced number of experiments, when compared with other reports in the literature; nevertheless, the final results lead to a statistically more reliable model.


  • Adsorption equilibrium isotherms, Confidence region, Fixed bed adsorptive unit, n-Propyl Propionate, Particle swarm optimization

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Field of science, Statistics Finland