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Classification of iPSC colony images using hierarchical strategies with support vector machines

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review


Original languageEnglish
Title of host publicationIEEE SSCI 2014 - 2014 IEEE Symposium Series on Computational Intelligence - CIDM 2014: 2014 IEEE Symposium on Computational Intelligence and Data Mining, Proceedings
PublisherThe Institute of Electrical and Electronics Engineers, Inc.
Number of pages7
ISBN (Print)9781479945191
Publication statusPublished - 13 Jan 2015
Publication typeA4 Article in a conference publication
EventIEEE Symposium on Computational Intelligence and Data Mining -
Duration: 1 Jan 1900 → …


ConferenceIEEE Symposium on Computational Intelligence and Data Mining
Period1/01/00 → …


In this preliminary research we examine the suitability of hierarchical strategies of multi-class support vector machines for classification of induced pluripotent stem cell (iPSC) colony images. The iPSC technology gives incredible possibilities for safe and patient specific drug therapy without any ethical problems. However, growing of iPSCs is a sensitive process and abnormalities may occur during the growing process. These abnormalities need to be recognized and the problem returns to image classification. We have a collection of 80 iPSC colony images where each one of the images is prelabeled by an expert to class bad, good or semigood. We use intensity histograms as features for classification and we evaluate histograms from the whole image and the colony area only having two datasets. We perform two feature reduction procedures for both datasets. In classification we examine how different hierarchical constructions effect the classification. We perform thorough evaluation and the best accuracy was around 54% obtained with the linear kernel function. Between different hierarchical structures, in many cases there are no significant changes in results. As a result, intensity histograms are a good baseline for the classification of iPSC colony images but more sophisticated feature extraction and reduction methods together with other classification methods need to be researched in future.

Publication forum classification

Field of science, Statistics Finland