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Common features of chromatin in aging and cancer: Cause or coincidence?

Research output: Contribution to journalReview ArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)686-694
Number of pages9
JournalTRENDS IN CELL BIOLOGY
Volume24
Issue number11
DOIs
Publication statusPublished - 2014
Publication typeA2 Review article in a scientific journal

Abstract

Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.

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