Common features of chromatin in aging and cancer: Cause or coincidence?
Research output: Contribution to journal › Review Article › Scientific › peer-review
|Number of pages||9|
|Journal||TRENDS IN CELL BIOLOGY|
|Publication status||Published - 2014|
|Publication type||A2 Review article in a scientific journal|
Age is a major risk factor for cancer. Alterations in DNA methylation, histone modifications, chromatin structure, and epigenetic regulatory mechanisms are prominent hallmarks of both the aging process and cancer. Intriguingly - or possibly coincidentally - several chromatin features are common between aging and cancer. Here we ask whether, and if so how, aging-associated chromatin modifications contribute to tumor susceptibility and tumorigenesis.