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Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: The Enlarged Prostate International Comparator Study (EPICS)

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Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia : The Enlarged Prostate International Comparator Study (EPICS). / Nickel, J. Curtis; Gilling, Peter; Tammela, Teuvo L.; Morrill, Betsy; Wilson, Timothy H.; Rittmaster, Roger S.

In: BJU International, Vol. 108, No. 3, 08.2011, p. 388-394.

Research output: Contribution to journalReview ArticleScientificpeer-review

Harvard

Nickel, JC, Gilling, P, Tammela, TL, Morrill, B, Wilson, TH & Rittmaster, RS 2011, 'Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: The Enlarged Prostate International Comparator Study (EPICS)', BJU International, vol. 108, no. 3, pp. 388-394. https://doi.org/10.1111/j.1464-410X.2011.10195.x

APA

Nickel, J. C., Gilling, P., Tammela, T. L., Morrill, B., Wilson, T. H., & Rittmaster, R. S. (2011). Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: The Enlarged Prostate International Comparator Study (EPICS). BJU International, 108(3), 388-394. https://doi.org/10.1111/j.1464-410X.2011.10195.x

Vancouver

Author

Nickel, J. Curtis ; Gilling, Peter ; Tammela, Teuvo L. ; Morrill, Betsy ; Wilson, Timothy H. ; Rittmaster, Roger S. / Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia : The Enlarged Prostate International Comparator Study (EPICS). In: BJU International. 2011 ; Vol. 108, No. 3. pp. 388-394.

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@article{f1c49bd8544e409b9447607ab92741ea,
title = "Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia: The Enlarged Prostate International Comparator Study (EPICS)",
abstract = "OBJECTIVE To assess the efficacy and safety of dutasteride compared with finasteride in treating men with symptomatic benign prostatic hyperplasia (BPH) for 12 months. PATIENTS AND METHODS The Enlarged Prostate International Comparator Study was a multicentre, randomized, double-blind, 12-month, parallel-group study. Men aged ≥50 years with a clinical diagnosis of BPH received once-daily treatment with dutasteride 0.5 mg (n= 813) or finasteride 5 mg (n= 817). After a 4-week placebo run-in period, patients were randomized to receive dutasteride or finasteride for 48 weeks, followed by an optional 24-month, open-label phase, during which patients received dutasteride 0.5 mg once daily. The primary endpoint was change in prostate volume, and the secondary endpoints included improvement in American Urological Association Symptom Index (AUA-SI) scores, improvement in maximum urinary flow rate (Q max) and long-term safety in the 24-month open-label phase. RESULTS Both dutasteride and finasteride were effective at reducing prostate volume with no significant difference between the two treatments during the study. Similar reductions in mean AUA-SI scores and Qmax were also observed for men in both treatment groups. A similar percentage of adverse events was experienced by patients of both treatment groups, and no new adverse events were reported in the open-label phase. CONCLUSION Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Qmax and urinary symptoms associated with BPH in men with an enlarged prostate.",
keywords = "5α-reductase inhibitors, benign prostatic hyperplasia, dutasteride, finasteride",
author = "Nickel, {J. Curtis} and Peter Gilling and Tammela, {Teuvo L.} and Betsy Morrill and Wilson, {Timothy H.} and Rittmaster, {Roger S.}",
year = "2011",
month = "8",
doi = "10.1111/j.1464-410X.2011.10195.x",
language = "English",
volume = "108",
pages = "388--394",
journal = "BJU International",
issn = "1464-4096",
publisher = "Wiley",
number = "3",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Comparison of dutasteride and finasteride for treating benign prostatic hyperplasia

T2 - The Enlarged Prostate International Comparator Study (EPICS)

AU - Nickel, J. Curtis

AU - Gilling, Peter

AU - Tammela, Teuvo L.

AU - Morrill, Betsy

AU - Wilson, Timothy H.

AU - Rittmaster, Roger S.

PY - 2011/8

Y1 - 2011/8

N2 - OBJECTIVE To assess the efficacy and safety of dutasteride compared with finasteride in treating men with symptomatic benign prostatic hyperplasia (BPH) for 12 months. PATIENTS AND METHODS The Enlarged Prostate International Comparator Study was a multicentre, randomized, double-blind, 12-month, parallel-group study. Men aged ≥50 years with a clinical diagnosis of BPH received once-daily treatment with dutasteride 0.5 mg (n= 813) or finasteride 5 mg (n= 817). After a 4-week placebo run-in period, patients were randomized to receive dutasteride or finasteride for 48 weeks, followed by an optional 24-month, open-label phase, during which patients received dutasteride 0.5 mg once daily. The primary endpoint was change in prostate volume, and the secondary endpoints included improvement in American Urological Association Symptom Index (AUA-SI) scores, improvement in maximum urinary flow rate (Q max) and long-term safety in the 24-month open-label phase. RESULTS Both dutasteride and finasteride were effective at reducing prostate volume with no significant difference between the two treatments during the study. Similar reductions in mean AUA-SI scores and Qmax were also observed for men in both treatment groups. A similar percentage of adverse events was experienced by patients of both treatment groups, and no new adverse events were reported in the open-label phase. CONCLUSION Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Qmax and urinary symptoms associated with BPH in men with an enlarged prostate.

AB - OBJECTIVE To assess the efficacy and safety of dutasteride compared with finasteride in treating men with symptomatic benign prostatic hyperplasia (BPH) for 12 months. PATIENTS AND METHODS The Enlarged Prostate International Comparator Study was a multicentre, randomized, double-blind, 12-month, parallel-group study. Men aged ≥50 years with a clinical diagnosis of BPH received once-daily treatment with dutasteride 0.5 mg (n= 813) or finasteride 5 mg (n= 817). After a 4-week placebo run-in period, patients were randomized to receive dutasteride or finasteride for 48 weeks, followed by an optional 24-month, open-label phase, during which patients received dutasteride 0.5 mg once daily. The primary endpoint was change in prostate volume, and the secondary endpoints included improvement in American Urological Association Symptom Index (AUA-SI) scores, improvement in maximum urinary flow rate (Q max) and long-term safety in the 24-month open-label phase. RESULTS Both dutasteride and finasteride were effective at reducing prostate volume with no significant difference between the two treatments during the study. Similar reductions in mean AUA-SI scores and Qmax were also observed for men in both treatment groups. A similar percentage of adverse events was experienced by patients of both treatment groups, and no new adverse events were reported in the open-label phase. CONCLUSION Dutasteride and finasteride, when administered for 12 months, were similarly effective in reducing prostate volume and improving Qmax and urinary symptoms associated with BPH in men with an enlarged prostate.

KW - 5α-reductase inhibitors

KW - benign prostatic hyperplasia

KW - dutasteride

KW - finasteride

UR - http://www.scopus.com/inward/record.url?scp=79960589121&partnerID=8YFLogxK

U2 - 10.1111/j.1464-410X.2011.10195.x

DO - 10.1111/j.1464-410X.2011.10195.x

M3 - Review Article

VL - 108

SP - 388

EP - 394

JO - BJU International

JF - BJU International

SN - 1464-4096

IS - 3

ER -