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Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling

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Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling. / Vignion-Dewalle, Anne Sophie; Betrouni, Nacim; Tylcz, Jean Baptiste; Vermandel, Maximilien; Mortier, Laurent; Mordon, Serge.

In: JOURNAL OF BIOMEDICAL OPTICS, Vol. 20, No. 5, 058001, 01.05.2015.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Vignion-Dewalle, AS, Betrouni, N, Tylcz, JB, Vermandel, M, Mortier, L & Mordon, S 2015, 'Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling', JOURNAL OF BIOMEDICAL OPTICS, vol. 20, no. 5, 058001. https://doi.org/10.1117/1.JBO.20.5.058001

APA

Vignion-Dewalle, A. S., Betrouni, N., Tylcz, J. B., Vermandel, M., Mortier, L., & Mordon, S. (2015). Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling. JOURNAL OF BIOMEDICAL OPTICS, 20(5), [058001]. https://doi.org/10.1117/1.JBO.20.5.058001

Vancouver

Vignion-Dewalle AS, Betrouni N, Tylcz JB, Vermandel M, Mortier L, Mordon S. Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling. JOURNAL OF BIOMEDICAL OPTICS. 2015 May 1;20(5). 058001. https://doi.org/10.1117/1.JBO.20.5.058001

Author

Vignion-Dewalle, Anne Sophie ; Betrouni, Nacim ; Tylcz, Jean Baptiste ; Vermandel, Maximilien ; Mortier, Laurent ; Mordon, Serge. / Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling. In: JOURNAL OF BIOMEDICAL OPTICS. 2015 ; Vol. 20, No. 5.

Bibtex - Download

@article{2c55cc3a0d434a82bbb53795d2e13314,
title = "Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling",
abstract = "Photodynamic therapy (PDT) is an emerging treatment modality for various diseases, especially for cancer therapy. Although high efficacy is demonstrated for PDT using standardized protocols in nonhyperkeratotic actinic keratoses, alternative light doses expected to increase efficiency, to reduce adverse effects or to expand the use of PDT, are still being evaluated and refined. We propose a comparison of the three most common light doses in the treatment of actinic keratosis with 5-aminolevulinic acid PDT through mathematical modeling. The proposed model is based on an iterative procedure that involves determination of the local fluence rate, updating of the local optical properties, and estimation of the local damage induced by the therapy. This model was applied on a simplified skin sample model including an actinic keratosis lesion, with three different light doses (red light dose, 37 J/cm2, 75 mW/cm2, 500 s; blue light dose, 10 J/cm2, 10 mW/cm2, 1000 s; and daylight dose, 9000 s). Results analysis shows that the three studied light doses, although all efficient, lead to variable local damage. Defining reference damage enables the nonoptimal parameters for the current light doses to be refined and the treatment to be more suitable",
keywords = "light doses comparison, mathematical modeling, photodynamic therapy, protoporphyrin IX",
author = "Vignion-Dewalle, {Anne Sophie} and Nacim Betrouni and Tylcz, {Jean Baptiste} and Maximilien Vermandel and Laurent Mortier and Serge Mordon",
year = "2015",
month = "5",
day = "1",
doi = "10.1117/1.JBO.20.5.058001",
language = "English",
volume = "20",
journal = "JOURNAL OF BIOMEDICAL OPTICS",
issn = "1083-3668",
publisher = "Society of Photo-optical Instrumentation Engineers",
number = "5",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Comparison of three light doses in the photodynamic treatment of actinic keratosis using mathematical modeling

AU - Vignion-Dewalle, Anne Sophie

AU - Betrouni, Nacim

AU - Tylcz, Jean Baptiste

AU - Vermandel, Maximilien

AU - Mortier, Laurent

AU - Mordon, Serge

PY - 2015/5/1

Y1 - 2015/5/1

N2 - Photodynamic therapy (PDT) is an emerging treatment modality for various diseases, especially for cancer therapy. Although high efficacy is demonstrated for PDT using standardized protocols in nonhyperkeratotic actinic keratoses, alternative light doses expected to increase efficiency, to reduce adverse effects or to expand the use of PDT, are still being evaluated and refined. We propose a comparison of the three most common light doses in the treatment of actinic keratosis with 5-aminolevulinic acid PDT through mathematical modeling. The proposed model is based on an iterative procedure that involves determination of the local fluence rate, updating of the local optical properties, and estimation of the local damage induced by the therapy. This model was applied on a simplified skin sample model including an actinic keratosis lesion, with three different light doses (red light dose, 37 J/cm2, 75 mW/cm2, 500 s; blue light dose, 10 J/cm2, 10 mW/cm2, 1000 s; and daylight dose, 9000 s). Results analysis shows that the three studied light doses, although all efficient, lead to variable local damage. Defining reference damage enables the nonoptimal parameters for the current light doses to be refined and the treatment to be more suitable

AB - Photodynamic therapy (PDT) is an emerging treatment modality for various diseases, especially for cancer therapy. Although high efficacy is demonstrated for PDT using standardized protocols in nonhyperkeratotic actinic keratoses, alternative light doses expected to increase efficiency, to reduce adverse effects or to expand the use of PDT, are still being evaluated and refined. We propose a comparison of the three most common light doses in the treatment of actinic keratosis with 5-aminolevulinic acid PDT through mathematical modeling. The proposed model is based on an iterative procedure that involves determination of the local fluence rate, updating of the local optical properties, and estimation of the local damage induced by the therapy. This model was applied on a simplified skin sample model including an actinic keratosis lesion, with three different light doses (red light dose, 37 J/cm2, 75 mW/cm2, 500 s; blue light dose, 10 J/cm2, 10 mW/cm2, 1000 s; and daylight dose, 9000 s). Results analysis shows that the three studied light doses, although all efficient, lead to variable local damage. Defining reference damage enables the nonoptimal parameters for the current light doses to be refined and the treatment to be more suitable

KW - light doses comparison

KW - mathematical modeling

KW - photodynamic therapy

KW - protoporphyrin IX

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U2 - 10.1117/1.JBO.20.5.058001

DO - 10.1117/1.JBO.20.5.058001

M3 - Article

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JO - JOURNAL OF BIOMEDICAL OPTICS

JF - JOURNAL OF BIOMEDICAL OPTICS

SN - 1083-3668

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