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Composites of hydrogels and nanoparticles: A potential solution to current challenges in buccal drug delivery

Research output: Chapter in Book/Report/Conference proceedingChapterScientificpeer-review

Details

Original languageEnglish
Title of host publicationBiopolymer-Based Composites
Subtitle of host publicationDrug Delivery and Biomedical Applications
PublisherWoodhead Publishing
Pages107-138
Number of pages32
ISBN (Electronic)9780081019153
ISBN (Print)9780081019146
DOIs
Publication statusPublished - 1 Jan 2017
Publication typeA3 Part of a book or another research book

Abstract

The buccal mucosa has emerged as an attractive route for local and systemic drug delivery. Owing to its unique anatomical and physiological features, the buccal mucosa offers advantages over more traditional routes. Its relative permeability and high degree of vascularization combined with the lack of keratinization lead to the rapid absorption of drugs, bypassing the hepatic first-pass metabolism and hydrolysis in the gastrointestinal tract. Conventional small molecule drugs and biologics have been administered through this route. However, the technological requirements and challenges associated with the buccal route have restricted the number of formulations available on the market or under clinical evaluation. In this chapter, nanoparticle hydrogel composites are presented as an innovative buccal drug delivery (BDD) system to overcome biopharmaceutical limitations related to the physiology and anatomy of the buccal route. The main developments in hydrogels, nanoparticles, and hybrid composites, as well as the formulation strategies, are reviewed here. In particular, we have focused on aspects related to permeability, mucoadhesion, and delivery of drugs with low solubility and poor bioavailability. New knowledge and directions to resolve challenges in BDD are summarized.

Keywords

  • Buccal drug delivery, Hydrogels, Mucoadhesion, Mucoadhesive polymers, Nanoparticle hydrogel composites, Nanosystems, Oral mucosa, Permeation

Publication forum classification

Field of science, Statistics Finland