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µCT based characterization of biomaterial scaffold microstructure under compression

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Details

Original languageEnglish
Title of host publicationWorld Congress on Medical Physics and Biomedical Engineering 2018
PublisherSpringer
Pages165-169
Number of pages5
ISBN (Electronic)978-981-10-9023-3
DOIs
StatePublished - 2019
Publication typeA4 Article in a conference publication
EventWorld Congress on Medical Physics and Biomedical Engineering -
Duration: 1 Jan 1900 → …

Publication series

NameIFMBE Proceedings
Number3
Volume68
ISSN (Print)1680-0737

Conference

ConferenceWorld Congress on Medical Physics and Biomedical Engineering
Period1/01/00 → …

Abstract

Scaffolds are often designed with progressive degradation to make way for cell proliferation of seeded cells for native tissue. The viability of the scaffold has been shown to depend on, among other things, the microstructure. Common parameters, that are used to describe microstructure, are porosity, material thickness, pore size and surface area. These properties quantify the suitability of the scaffold as a substrate for cell adhesion, fluid exchange and nutrient transfer. Bone and cartilage scaffolds are often placed or operated under loads (predominantly compression). This can alter the structural parameters depending on the stiffness of the scaffold and applied deformation. It is important to know, how scaffolds’ parameters change under deformation. In this study, two scaffolds (PLCL-TCP and collagen-PLA) intended for use in bone and cartilage applications, were studied through micro computed tomography based imaging and in situ mechanical testing. The scaffolds were subjected to uniaxial compressive deformation up to 50% of the original size. The corresponding changes in the individual scaffold bulk characteristics were analyzed. Our results show an expected decrease in porosity with increasing deformation (with PLCL-TCP scaffold 52% deformation resulted in 56% decrease in porosity). Especially in the sandwich constructs of collagen-PLA, but also in PLCL-TCP composites, it was evident that different materials are affected differently which may be of significance in applications with mechanical loading. Our results are a step towards understanding the changes in the structure of these scaffolds under loading.

ASJC Scopus subject areas

Keywords

  • Biomaterials, Compression, In situ imaging, Porosity, X-ray microtomography

Publication forum classification

Field of science, Statistics Finland