Detection beyond Debye's length with an electrolyte-gated organic field-effect transistor
Research output: Contribution to journal › Article › Scientific › peer-review
|Number of pages||6|
|Publication status||Published - 2015|
|Publication type||A1 Journal article-refereed|
A systematic study of the sensor response as a function of the Debye's length, the receptor charge, and the distance at which the binding event occurred addressed the basic functional mechanisms of a bio-electrolyte-gated organic field-effect transistors (EGOFET). A bio-EGOFET sensing platform comprising a biological layer at the interface between the OSC and the electrolyte was used to conduct the investigations. The biological layer was composed of a phospholipid (PL) bilayer covalently anchored to the OSC surface through a plasma-deposited (?COOH)-functionalized thin coating. It was observed that some of the anchored PLs were endowed with a biotin moiety, having an incomparably high binding affinity for streptavidin (SA) or avidin (AV) proteins.