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Detection beyond Debye's length with an electrolyte-gated organic field-effect transistor

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Original languageEnglish
Pages (from-to)911-916
Number of pages6
JournalAdvanced Materials
Issue number5
Publication statusPublished - 2015
Publication typeA1 Journal article-refereed


A systematic study of the sensor response as a function of the Debye's length, the receptor charge, and the distance at which the binding event occurred addressed the basic functional mechanisms of a bio-electrolyte-gated organic field-effect transistors (EGOFET). A bio-EGOFET sensing platform comprising a biological layer at the interface between the OSC and the electrolyte was used to conduct the investigations. The biological layer was composed of a phospholipid (PL) bilayer covalently anchored to the OSC surface through a plasma-deposited (?COOH)-functionalized thin coating. It was observed that some of the anchored PLs were endowed with a biotin moiety, having an incomparably high binding affinity for streptavidin (SA) or avidin (AV) proteins.