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Detection of Pancreatic Cancer by Urine Volatile Organic Compound Analysis

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalAnticancer Research
Volume39
Issue number1
Early online date2018
DOIs
Publication statusPublished - Jan 2019
Publication typeA1 Journal article-refereed

Abstract

BACKGROUND/AIM: Most pancreatic cancer patients are diagnosed at an advanced stage, since the diagnosis is demanding. Field asymmetric waveform ion mobility spectrometry (FAIMS) is a sensitive technique used for the detection of volatile organic compounds (VOC). We evaluated the ability of FAIMS to discriminate between pancreatic cancer and healthy controls from a urine sample. PATIENTS AND METHODS: For a proof-of-concept study in three Finnish hospitals, 68 patients with pancreatic cancer, 36 with acute pancreatitis, 18 with chronic pancreatitis, 8 with pancreatic pre-malign lesions and 52 healthy controls were prospectively recruited. Urine samples were collected at the time of diagnosis and stored at -70°C. The samples were subsequently measured with FAIMS. The data were processed with linear discriminant analysis and cross-validated with leave-one-out cross-validation. RESULTS: FAIMS distinguished pancreatic cancer from controls with a sensitivity of 79% and specificity of 79%. CONCLUSION: As a non-invasive and rapid urine test, FAIMS can discriminate patients with pancreatic cancer from healthy controls.

ASJC Scopus subject areas

Keywords

  • FAIMS, linear discriminant analysis, Pancreatic cancer, pre-malignant lesion, urine test, volatile organic compound

Publication forum classification

Field of science, Statistics Finland