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Direct Measurement of Contraction Force in Human Cardiac Tissue Model Using Piezoelectric Cantilever Sensor Technique

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)155-160
Number of pages6
JournalCurrent Applied Physics
Volume20
Issue number1
DOIs
Publication statusAccepted/In press - 25 Oct 2019
Publication typeA1 Journal article-refereed

Abstract

A proof-of-concept method for measuring cardiac tissue contraction force using an in-house-developed piezoelectric cantilever sensor system is demonstrated. Contracting forces of 7.2 to 16.6 μN were measured from a human cardiac tissue construct. Beating cardiac tissue constructs were monitored in-situ under a microscope during the contraction force measurements. Development of the measurement method allows very low forces such as the ones that appear in biological small scale systems to be determined.

Keywords

  • cardiomyocyte, piezoelectric sensor, cantilever, contraction force

Publication forum classification

Field of science, Statistics Finland