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Disease-associated inflammatory biomarker profiles in blood in different subtypes of multiple sclerosis: Prospective clinical and MRI follow-up study

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Disease-associated inflammatory biomarker profiles in blood in different subtypes of multiple sclerosis : Prospective clinical and MRI follow-up study. / Hagman, Sanna; Raunio, Minna; Rossi, Maija; Dastidar, Prasun; Elovaara, Irina.

In: JOURNAL OF NEUROIMMUNOLOGY, Vol. 234, No. 1-2, 05.2011, p. 141-147.

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Hagman, Sanna ; Raunio, Minna ; Rossi, Maija ; Dastidar, Prasun ; Elovaara, Irina. / Disease-associated inflammatory biomarker profiles in blood in different subtypes of multiple sclerosis : Prospective clinical and MRI follow-up study. In: JOURNAL OF NEUROIMMUNOLOGY. 2011 ; Vol. 234, No. 1-2. pp. 141-147.

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@article{d879f00de832417ea8bf22c633872a30,
title = "Disease-associated inflammatory biomarker profiles in blood in different subtypes of multiple sclerosis: Prospective clinical and MRI follow-up study",
abstract = "To identify biomarkers of disease activity and progression in multiple sclerosis (MS), we analyzed the serum profiles of cytokines, chemokines and apoptotic molecules in different subtypes of MS including clinically isolated syndrome (CIS) and correlated their levels with clinical and volumetric MRI findings obtained over a one-year follow up. Upregulated levels of apoptotic sFas molecule were found in MS patients with a worsening EDSS score and an accumulation of hypointense lesions in MRI. In such patients, the levels of MIF appeared to be higher than in non-progressing patients. In addition, increased levels of serum TNF-α and CCL2 were found especially in primary progressive MS (PPMS). These observations suggest that serum Fas and MIF are candidate biomarkers of neurological worsening related to progressive neurodegeneration, while serum TNF-α and CCL2 reflect the presence of inflammatory responses in PPMS.",
keywords = "Apoptosis, Biomarkers, Chemokines, Cytokines, Expanded disability status scale, Magnetic resonance imaging, Multiple sclerosis",
author = "Sanna Hagman and Minna Raunio and Maija Rossi and Prasun Dastidar and Irina Elovaara",
year = "2011",
month = "5",
doi = "10.1016/j.jneuroim.2011.02.009",
language = "English",
volume = "234",
pages = "141--147",
journal = "JOURNAL OF NEUROIMMUNOLOGY",
issn = "0165-5728",
publisher = "Elsevier",
number = "1-2",

}

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TY - JOUR

T1 - Disease-associated inflammatory biomarker profiles in blood in different subtypes of multiple sclerosis

T2 - Prospective clinical and MRI follow-up study

AU - Hagman, Sanna

AU - Raunio, Minna

AU - Rossi, Maija

AU - Dastidar, Prasun

AU - Elovaara, Irina

PY - 2011/5

Y1 - 2011/5

N2 - To identify biomarkers of disease activity and progression in multiple sclerosis (MS), we analyzed the serum profiles of cytokines, chemokines and apoptotic molecules in different subtypes of MS including clinically isolated syndrome (CIS) and correlated their levels with clinical and volumetric MRI findings obtained over a one-year follow up. Upregulated levels of apoptotic sFas molecule were found in MS patients with a worsening EDSS score and an accumulation of hypointense lesions in MRI. In such patients, the levels of MIF appeared to be higher than in non-progressing patients. In addition, increased levels of serum TNF-α and CCL2 were found especially in primary progressive MS (PPMS). These observations suggest that serum Fas and MIF are candidate biomarkers of neurological worsening related to progressive neurodegeneration, while serum TNF-α and CCL2 reflect the presence of inflammatory responses in PPMS.

AB - To identify biomarkers of disease activity and progression in multiple sclerosis (MS), we analyzed the serum profiles of cytokines, chemokines and apoptotic molecules in different subtypes of MS including clinically isolated syndrome (CIS) and correlated their levels with clinical and volumetric MRI findings obtained over a one-year follow up. Upregulated levels of apoptotic sFas molecule were found in MS patients with a worsening EDSS score and an accumulation of hypointense lesions in MRI. In such patients, the levels of MIF appeared to be higher than in non-progressing patients. In addition, increased levels of serum TNF-α and CCL2 were found especially in primary progressive MS (PPMS). These observations suggest that serum Fas and MIF are candidate biomarkers of neurological worsening related to progressive neurodegeneration, while serum TNF-α and CCL2 reflect the presence of inflammatory responses in PPMS.

KW - Apoptosis

KW - Biomarkers

KW - Chemokines

KW - Cytokines

KW - Expanded disability status scale

KW - Magnetic resonance imaging

KW - Multiple sclerosis

UR - http://www.scopus.com/inward/record.url?scp=79955673049&partnerID=8YFLogxK

U2 - 10.1016/j.jneuroim.2011.02.009

DO - 10.1016/j.jneuroim.2011.02.009

M3 - Article

VL - 234

SP - 141

EP - 147

JO - JOURNAL OF NEUROIMMUNOLOGY

JF - JOURNAL OF NEUROIMMUNOLOGY

SN - 0165-5728

IS - 1-2

ER -