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Early effects of adjuvant breast cancer radiotherapy on right ventricular systolic and diastolic function

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)2141-2147
Number of pages7
JournalAnticancer Research
Volume35
Issue number4
Publication statusPublished - 1 Apr 2015
Publication typeA1 Journal article-refereed

Abstract

Aim: Reduced right ventricular (RV) systolic function correlates with poor prognosis in several heart diseases. The aim of this prospective single-Center study was to investigate whether conformal three-dimensional (3D) breast cancer radiotherapy impairs RV function. Patients and Methods: Forty-nine patients with early-stage left-sided breast cancer underwent comprehensive two-dimensional (2D) echocardiography before and after radiotherapy. RV function was evaluated with tricuspid annular plane systolic excursion (TAPSE), pulsed tissue Doppler peak velocity at the lateral RV wall (S') and RV and venous flow analysis. Results: Radiotherapy reduced TAPSE from 24.5±4.0 mm to 22.4±3.9 mm (p

ASJC Scopus subject areas

Keywords

  • Breast cancer, Radiotherapy, Right ventricle, TAPSE