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ECG T-wave amplitude changes during thiopentone induction with or without alfentanil

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ECG T-wave amplitude changes during thiopentone induction with or without alfentanil. / Annila, Päivi; Lindgren, Leena; Loula, Pekka ; Dunkel, Paula; Annila, Ilkka; Yli-Hankala, Arvi.

In: ACTA ANAESTHESIOLOGICA SCANDINAVICA, Vol. 39, No. 3, 1995, p. 401-405.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Annila, P, Lindgren, L, Loula, P, Dunkel, P, Annila, I & Yli-Hankala, A 1995, 'ECG T-wave amplitude changes during thiopentone induction with or without alfentanil', ACTA ANAESTHESIOLOGICA SCANDINAVICA, vol. 39, no. 3, pp. 401-405.

APA

Annila, P., Lindgren, L., Loula, P., Dunkel, P., Annila, I., & Yli-Hankala, A. (1995). ECG T-wave amplitude changes during thiopentone induction with or without alfentanil. ACTA ANAESTHESIOLOGICA SCANDINAVICA, 39(3), 401-405.

Vancouver

Annila P, Lindgren L, Loula P, Dunkel P, Annila I, Yli-Hankala A. ECG T-wave amplitude changes during thiopentone induction with or without alfentanil. ACTA ANAESTHESIOLOGICA SCANDINAVICA. 1995;39(3):401-405.

Author

Annila, Päivi ; Lindgren, Leena ; Loula, Pekka ; Dunkel, Paula ; Annila, Ilkka ; Yli-Hankala, Arvi. / ECG T-wave amplitude changes during thiopentone induction with or without alfentanil. In: ACTA ANAESTHESIOLOGICA SCANDINAVICA. 1995 ; Vol. 39, No. 3. pp. 401-405.

Bibtex - Download

@article{dcf16c5fa6324c8e83e4ebbc5f7788a9,
title = "ECG T-wave amplitude changes during thiopentone induction with or without alfentanil",
abstract = "The T-wave amplitude of ECG is thought to reflect the sympathetic tone of the heart but anaesthesia studies on this topic are rare. Haemodynamic and ECG T-wave amplitude changes were studied during induction of anaesthesia in 24 ASA I-II patients. Twelve patients were given alfentanil 30 μg kg-1 at induction while physiologic saline was given to the rest (control). Thiopentone was then administered at the rate of 5 mg s-1 until eyelash reflex disappeared. Vecuronium 0.1 mg kg-1 was given thereafter. No anticholinergics were used. The lungs were ventilated with 40{\%} oxygen in air. Haemodynamic parametres and T-wave amplitude were measured before induction, before intubation, 30 s, 3 min and 5 min after intubation. A significandy higher amount of thiopentone was needed to abolish the eyelash reflex in the control group than in the alfentanil group (P<0.001). There were no changes in heart rate (HR) in the alfentanil group during the trial. Systolic and diastolic arterial pressures (SAP and DAP) were continuously below the preinduction levels in the alfentanil group. After baseline HR, SAP and DAP were significantly higher in the control group than in the alfentanil group at each data point. T-wave amplitude flattened significantly (P<0.001) after intubation in the control group while no significant changes were seen in the alfentanil group. T-wave flattening correlated to the increases in HR (P<0.01) and SAP (P<0.01). Three control patients with flattened T-wave had a transient bigeminia period after intubation. It is concluded that ECG T-wave amplitude flattening was associated with pressure and heart rate response to laryngoscopy and intubation. Alfentanil blunted these responses and prevented T-wave changes after intubation.",
author = "P{\"a}ivi Annila and Leena Lindgren and Pekka Loula and Paula Dunkel and Ilkka Annila and Arvi Yli-Hankala",
year = "1995",
language = "English",
volume = "39",
pages = "401--405",
journal = "ACTA ANAESTHESIOLOGICA SCANDINAVICA",
issn = "0001-5172",
publisher = "Wiley",
number = "3",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - ECG T-wave amplitude changes during thiopentone induction with or without alfentanil

AU - Annila, Päivi

AU - Lindgren, Leena

AU - Loula, Pekka

AU - Dunkel, Paula

AU - Annila, Ilkka

AU - Yli-Hankala, Arvi

PY - 1995

Y1 - 1995

N2 - The T-wave amplitude of ECG is thought to reflect the sympathetic tone of the heart but anaesthesia studies on this topic are rare. Haemodynamic and ECG T-wave amplitude changes were studied during induction of anaesthesia in 24 ASA I-II patients. Twelve patients were given alfentanil 30 μg kg-1 at induction while physiologic saline was given to the rest (control). Thiopentone was then administered at the rate of 5 mg s-1 until eyelash reflex disappeared. Vecuronium 0.1 mg kg-1 was given thereafter. No anticholinergics were used. The lungs were ventilated with 40% oxygen in air. Haemodynamic parametres and T-wave amplitude were measured before induction, before intubation, 30 s, 3 min and 5 min after intubation. A significandy higher amount of thiopentone was needed to abolish the eyelash reflex in the control group than in the alfentanil group (P<0.001). There were no changes in heart rate (HR) in the alfentanil group during the trial. Systolic and diastolic arterial pressures (SAP and DAP) were continuously below the preinduction levels in the alfentanil group. After baseline HR, SAP and DAP were significantly higher in the control group than in the alfentanil group at each data point. T-wave amplitude flattened significantly (P<0.001) after intubation in the control group while no significant changes were seen in the alfentanil group. T-wave flattening correlated to the increases in HR (P<0.01) and SAP (P<0.01). Three control patients with flattened T-wave had a transient bigeminia period after intubation. It is concluded that ECG T-wave amplitude flattening was associated with pressure and heart rate response to laryngoscopy and intubation. Alfentanil blunted these responses and prevented T-wave changes after intubation.

AB - The T-wave amplitude of ECG is thought to reflect the sympathetic tone of the heart but anaesthesia studies on this topic are rare. Haemodynamic and ECG T-wave amplitude changes were studied during induction of anaesthesia in 24 ASA I-II patients. Twelve patients were given alfentanil 30 μg kg-1 at induction while physiologic saline was given to the rest (control). Thiopentone was then administered at the rate of 5 mg s-1 until eyelash reflex disappeared. Vecuronium 0.1 mg kg-1 was given thereafter. No anticholinergics were used. The lungs were ventilated with 40% oxygen in air. Haemodynamic parametres and T-wave amplitude were measured before induction, before intubation, 30 s, 3 min and 5 min after intubation. A significandy higher amount of thiopentone was needed to abolish the eyelash reflex in the control group than in the alfentanil group (P<0.001). There were no changes in heart rate (HR) in the alfentanil group during the trial. Systolic and diastolic arterial pressures (SAP and DAP) were continuously below the preinduction levels in the alfentanil group. After baseline HR, SAP and DAP were significantly higher in the control group than in the alfentanil group at each data point. T-wave amplitude flattened significantly (P<0.001) after intubation in the control group while no significant changes were seen in the alfentanil group. T-wave flattening correlated to the increases in HR (P<0.01) and SAP (P<0.01). Three control patients with flattened T-wave had a transient bigeminia period after intubation. It is concluded that ECG T-wave amplitude flattening was associated with pressure and heart rate response to laryngoscopy and intubation. Alfentanil blunted these responses and prevented T-wave changes after intubation.

M3 - Article

VL - 39

SP - 401

EP - 405

JO - ACTA ANAESTHESIOLOGICA SCANDINAVICA

JF - ACTA ANAESTHESIOLOGICA SCANDINAVICA

SN - 0001-5172

IS - 3

ER -