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Effect of melt-derived bioactive glass particles on the properties of chitosan scaffolds

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Effect of melt-derived bioactive glass particles on the properties of chitosan scaffolds. / Faqhiri, Hamasa; Hannula, Markus; Kellomäki, Minna; Calejo, Maria Teresa; Massera, Jonathan.

In: JOURNAL OF FUNCTIONAL BIOMATERIALS, Vol. 10, No. 3, 38, 01.09.2019.

Research output: Contribution to journalArticleScientificpeer-review

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Faqhiri, Hamasa ; Hannula, Markus ; Kellomäki, Minna ; Calejo, Maria Teresa ; Massera, Jonathan. / Effect of melt-derived bioactive glass particles on the properties of chitosan scaffolds. In: JOURNAL OF FUNCTIONAL BIOMATERIALS. 2019 ; Vol. 10, No. 3.

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@article{d1ffb39197b543d8ae6dd797bf2f91de,
title = "Effect of melt-derived bioactive glass particles on the properties of chitosan scaffolds",
abstract = "This study reports on the processing of three-dimensional (3D) chitosan/bioactive glass composite scaffolds. On the one hand, chitosan, as a natural polymer, has suitable properties for tissue engineering applications but lacks bioactivity. On the other hand, bioactive glasses are known to be bioactive and to promote a higher level of bone formation than any other biomaterial type. However, bioactive glasses are hard, brittle, and cannot be shaped easily. Therefore, in the past years, researchers have focused on the processing of new composites. Difficulties in reaching composite materials made of polymer (synthetic or natural) and bioactive glass include: (i) The high glass density, often resulting in glass segregation, and (ii) the fast bioactive glass reaction when exposed to moisture, leading to changes in the glass reactivity and/or change in the polymeric matrix. Samples were prepared with 5, 15, and 30 wt{\%} of bioactive glass S53P4 (BonAlive {\circledR}), as confirmed using thermogravimetric analysis. MicrO–Computed tomography and optical microscopy revealed a flaky structure with porosity over 80{\%}. The pore size decreased when increasing the glass content up to 15 wt{\%}, but increased back when the glass content was 30 wt{\%}. Similarly, the mechanical properties (in compression) of the scaffolds increased for glass content up to 15{\%}, but decreased at higher loading. Ions released from the scaffolds were found to lead to precipitation of a calcium phosphate reactive layer at the scaffold surface. This is a first indication of the potential bioactivity of these materials. Overall, chitosan/bioactive glass composite scaffolds were successfully produced with pore size, machinability, and ability to promote a calcium phosphate layer, showing promise for bone tissue engineering and the mechanical properties can justify their use in non-load bearing applications.",
keywords = "Bioactive glass, Bone tissue engineering, Chitosan, Composites",
author = "Hamasa Faqhiri and Markus Hannula and Minna Kellom{\"a}ki and Calejo, {Maria Teresa} and Jonathan Massera",
note = "INT=bmte,{"}Faqhiri, Hamasa{"} dupl=50709653",
year = "2019",
month = "9",
day = "1",
doi = "10.3390/jfb10030038",
language = "English",
volume = "10",
journal = "JOURNAL OF FUNCTIONAL BIOMATERIALS",
issn = "2079-4983",
publisher = "MDPI AG",
number = "3",

}

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TY - JOUR

T1 - Effect of melt-derived bioactive glass particles on the properties of chitosan scaffolds

AU - Faqhiri, Hamasa

AU - Hannula, Markus

AU - Kellomäki, Minna

AU - Calejo, Maria Teresa

AU - Massera, Jonathan

N1 - INT=bmte,"Faqhiri, Hamasa" dupl=50709653

PY - 2019/9/1

Y1 - 2019/9/1

N2 - This study reports on the processing of three-dimensional (3D) chitosan/bioactive glass composite scaffolds. On the one hand, chitosan, as a natural polymer, has suitable properties for tissue engineering applications but lacks bioactivity. On the other hand, bioactive glasses are known to be bioactive and to promote a higher level of bone formation than any other biomaterial type. However, bioactive glasses are hard, brittle, and cannot be shaped easily. Therefore, in the past years, researchers have focused on the processing of new composites. Difficulties in reaching composite materials made of polymer (synthetic or natural) and bioactive glass include: (i) The high glass density, often resulting in glass segregation, and (ii) the fast bioactive glass reaction when exposed to moisture, leading to changes in the glass reactivity and/or change in the polymeric matrix. Samples were prepared with 5, 15, and 30 wt% of bioactive glass S53P4 (BonAlive ®), as confirmed using thermogravimetric analysis. MicrO–Computed tomography and optical microscopy revealed a flaky structure with porosity over 80%. The pore size decreased when increasing the glass content up to 15 wt%, but increased back when the glass content was 30 wt%. Similarly, the mechanical properties (in compression) of the scaffolds increased for glass content up to 15%, but decreased at higher loading. Ions released from the scaffolds were found to lead to precipitation of a calcium phosphate reactive layer at the scaffold surface. This is a first indication of the potential bioactivity of these materials. Overall, chitosan/bioactive glass composite scaffolds were successfully produced with pore size, machinability, and ability to promote a calcium phosphate layer, showing promise for bone tissue engineering and the mechanical properties can justify their use in non-load bearing applications.

AB - This study reports on the processing of three-dimensional (3D) chitosan/bioactive glass composite scaffolds. On the one hand, chitosan, as a natural polymer, has suitable properties for tissue engineering applications but lacks bioactivity. On the other hand, bioactive glasses are known to be bioactive and to promote a higher level of bone formation than any other biomaterial type. However, bioactive glasses are hard, brittle, and cannot be shaped easily. Therefore, in the past years, researchers have focused on the processing of new composites. Difficulties in reaching composite materials made of polymer (synthetic or natural) and bioactive glass include: (i) The high glass density, often resulting in glass segregation, and (ii) the fast bioactive glass reaction when exposed to moisture, leading to changes in the glass reactivity and/or change in the polymeric matrix. Samples were prepared with 5, 15, and 30 wt% of bioactive glass S53P4 (BonAlive ®), as confirmed using thermogravimetric analysis. MicrO–Computed tomography and optical microscopy revealed a flaky structure with porosity over 80%. The pore size decreased when increasing the glass content up to 15 wt%, but increased back when the glass content was 30 wt%. Similarly, the mechanical properties (in compression) of the scaffolds increased for glass content up to 15%, but decreased at higher loading. Ions released from the scaffolds were found to lead to precipitation of a calcium phosphate reactive layer at the scaffold surface. This is a first indication of the potential bioactivity of these materials. Overall, chitosan/bioactive glass composite scaffolds were successfully produced with pore size, machinability, and ability to promote a calcium phosphate layer, showing promise for bone tissue engineering and the mechanical properties can justify their use in non-load bearing applications.

KW - Bioactive glass

KW - Bone tissue engineering

KW - Chitosan

KW - Composites

U2 - 10.3390/jfb10030038

DO - 10.3390/jfb10030038

M3 - Article

VL - 10

JO - JOURNAL OF FUNCTIONAL BIOMATERIALS

JF - JOURNAL OF FUNCTIONAL BIOMATERIALS

SN - 2079-4983

IS - 3

M1 - 38

ER -