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Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding

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Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding. / Rantanen, Tuomo; Udd, Marianne; Honkanen, Teemu; Miettinen, Pekka; Kärjä, Vesa; Rantanen, Lassi; Julkunen, Risto; Mustonen, Harri; Paavonen, Timo; Oksala, Niku.

In: Digestive Diseases and Sciences, Vol. 59, No. 11, 20.08.2014, p. 2666-2674.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Rantanen, T, Udd, M, Honkanen, T, Miettinen, P, Kärjä, V, Rantanen, L, Julkunen, R, Mustonen, H, Paavonen, T & Oksala, N 2014, 'Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding', Digestive Diseases and Sciences, vol. 59, no. 11, pp. 2666-2674. https://doi.org/10.1007/s10620-014-3242-z

APA

Rantanen, T., Udd, M., Honkanen, T., Miettinen, P., Kärjä, V., Rantanen, L., ... Oksala, N. (2014). Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding. Digestive Diseases and Sciences, 59(11), 2666-2674. https://doi.org/10.1007/s10620-014-3242-z

Vancouver

Rantanen T, Udd M, Honkanen T, Miettinen P, Kärjä V, Rantanen L et al. Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding. Digestive Diseases and Sciences. 2014 Aug 20;59(11):2666-2674. https://doi.org/10.1007/s10620-014-3242-z

Author

Rantanen, Tuomo ; Udd, Marianne ; Honkanen, Teemu ; Miettinen, Pekka ; Kärjä, Vesa ; Rantanen, Lassi ; Julkunen, Risto ; Mustonen, Harri ; Paavonen, Timo ; Oksala, Niku. / Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding. In: Digestive Diseases and Sciences. 2014 ; Vol. 59, No. 11. pp. 2666-2674.

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@article{bd4bdd9dacd44908b164e718b1919f22,
title = "Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding",
abstract = "Background: Peptic ulcer bleeding (PUB) is a major cause of upper gastrointestinal bleeding. The effect of omeprazole on mucosal repair is unknown. Aims: We studied the effect of omeprazole, nonsteroidal anti-inflammatory agents, and smoking on PUB. Methods: There were 43 PUB patients who received regular or high dose of omeprazole for 72 h. Biopsies from antrum and corpus were taken before and after treatment. Biopsy samples from 20 celiac disease patients worked as controls. The expression of Ki-67, Bcl-2, COX-2, Hsp27, and Hsp70 was analyzed from patients and controls. Results: Bcl-2 expression in PUB patients was lower than in controls. However, Bcl-2 increased significantly from 5.0 (SD 4.5) to 9.1 {\%} (SD 6.7), p = 0.0004, in the antrum after omeprazole. In univariate analysis, a high omeprazole dose caused a more profound increase in Ki-67 expression in the corpus: 35.3 {\%} (SD 54.8) than a regular dose: −10.1 {\%} (SD 40.6), p = 0.022. In multivariate analysis, Ki-67 decreased significantly in the corpus between the pre- and posttreatment period (p = 0.011), while a high omeprazole dose (p = 0.0265), the use of NSAIDs (p = 0.0208), and smoking (p = 0.0296) significantly increased Ki-67 expression. Bcl-2 in the corpus increased significantly (p = 0.0003) after treatment. Conclusions: Our findings suggest that Bcl-2 may be an important factor in the pathogenesis of a peptic ulcer and PUB. In addition, high-dose omeprazole increased the expression of Ki-67, which may enhance the healing process of a peptic ulcer.",
keywords = "High and regular dose, Nonsteroidal anti-inflammatory agents, Omeprazole, Peptic ulcer bleeding, Repair mechanisms, Smoking",
author = "Tuomo Rantanen and Marianne Udd and Teemu Honkanen and Pekka Miettinen and Vesa K{\"a}rj{\"a} and Lassi Rantanen and Risto Julkunen and Harri Mustonen and Timo Paavonen and Niku Oksala",
year = "2014",
month = "8",
day = "20",
doi = "10.1007/s10620-014-3242-z",
language = "English",
volume = "59",
pages = "2666--2674",
journal = "Digestive Diseases and Sciences",
issn = "0163-2116",
publisher = "Springer Verlag",
number = "11",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Effect of Omeprazole Dose, Nonsteroidal Anti-inflammatory Agents, and Smoking on Repair Mechanisms in Acute Peptic Ulcer Bleeding

AU - Rantanen, Tuomo

AU - Udd, Marianne

AU - Honkanen, Teemu

AU - Miettinen, Pekka

AU - Kärjä, Vesa

AU - Rantanen, Lassi

AU - Julkunen, Risto

AU - Mustonen, Harri

AU - Paavonen, Timo

AU - Oksala, Niku

PY - 2014/8/20

Y1 - 2014/8/20

N2 - Background: Peptic ulcer bleeding (PUB) is a major cause of upper gastrointestinal bleeding. The effect of omeprazole on mucosal repair is unknown. Aims: We studied the effect of omeprazole, nonsteroidal anti-inflammatory agents, and smoking on PUB. Methods: There were 43 PUB patients who received regular or high dose of omeprazole for 72 h. Biopsies from antrum and corpus were taken before and after treatment. Biopsy samples from 20 celiac disease patients worked as controls. The expression of Ki-67, Bcl-2, COX-2, Hsp27, and Hsp70 was analyzed from patients and controls. Results: Bcl-2 expression in PUB patients was lower than in controls. However, Bcl-2 increased significantly from 5.0 (SD 4.5) to 9.1 % (SD 6.7), p = 0.0004, in the antrum after omeprazole. In univariate analysis, a high omeprazole dose caused a more profound increase in Ki-67 expression in the corpus: 35.3 % (SD 54.8) than a regular dose: −10.1 % (SD 40.6), p = 0.022. In multivariate analysis, Ki-67 decreased significantly in the corpus between the pre- and posttreatment period (p = 0.011), while a high omeprazole dose (p = 0.0265), the use of NSAIDs (p = 0.0208), and smoking (p = 0.0296) significantly increased Ki-67 expression. Bcl-2 in the corpus increased significantly (p = 0.0003) after treatment. Conclusions: Our findings suggest that Bcl-2 may be an important factor in the pathogenesis of a peptic ulcer and PUB. In addition, high-dose omeprazole increased the expression of Ki-67, which may enhance the healing process of a peptic ulcer.

AB - Background: Peptic ulcer bleeding (PUB) is a major cause of upper gastrointestinal bleeding. The effect of omeprazole on mucosal repair is unknown. Aims: We studied the effect of omeprazole, nonsteroidal anti-inflammatory agents, and smoking on PUB. Methods: There were 43 PUB patients who received regular or high dose of omeprazole for 72 h. Biopsies from antrum and corpus were taken before and after treatment. Biopsy samples from 20 celiac disease patients worked as controls. The expression of Ki-67, Bcl-2, COX-2, Hsp27, and Hsp70 was analyzed from patients and controls. Results: Bcl-2 expression in PUB patients was lower than in controls. However, Bcl-2 increased significantly from 5.0 (SD 4.5) to 9.1 % (SD 6.7), p = 0.0004, in the antrum after omeprazole. In univariate analysis, a high omeprazole dose caused a more profound increase in Ki-67 expression in the corpus: 35.3 % (SD 54.8) than a regular dose: −10.1 % (SD 40.6), p = 0.022. In multivariate analysis, Ki-67 decreased significantly in the corpus between the pre- and posttreatment period (p = 0.011), while a high omeprazole dose (p = 0.0265), the use of NSAIDs (p = 0.0208), and smoking (p = 0.0296) significantly increased Ki-67 expression. Bcl-2 in the corpus increased significantly (p = 0.0003) after treatment. Conclusions: Our findings suggest that Bcl-2 may be an important factor in the pathogenesis of a peptic ulcer and PUB. In addition, high-dose omeprazole increased the expression of Ki-67, which may enhance the healing process of a peptic ulcer.

KW - High and regular dose

KW - Nonsteroidal anti-inflammatory agents

KW - Omeprazole

KW - Peptic ulcer bleeding

KW - Repair mechanisms

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=84922393478&partnerID=8YFLogxK

U2 - 10.1007/s10620-014-3242-z

DO - 10.1007/s10620-014-3242-z

M3 - Article

VL - 59

SP - 2666

EP - 2674

JO - Digestive Diseases and Sciences

JF - Digestive Diseases and Sciences

SN - 0163-2116

IS - 11

ER -