Tampere University of Technology

TUTCRIS Research Portal

Effects of local structure of neuronal networks on spiking activity in silico

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Details

Original languageEnglish
Title of host publicationTwentieth Annual Computational Neuroscience Meeting: CNS*2011
EditorsJean-Marc Fellous, Astrid Prinz
Place of PublicationStockholm
PublisherBioMed Central
PagesP202
Number of pages1
Volume12 (Suppl 1)
Publication statusPublished - 18 Jul 2011
Publication typeNot Eligible
EventTwentieth Annual Computational Neuroscience Meeting: CNS*2011 - Stockholm, Sweden
Duration: 23 Jul 201128 Jul 2011

Conference

ConferenceTwentieth Annual Computational Neuroscience Meeting: CNS*2011
CountrySweden
CityStockholm
Period23/07/1128/07/11

Abstract

The structure of the neuronal network, including synaptic connectivity, is the basis for information transfer in the network. Various graph-theoretic measures such as degree distribution, mean geodesic path length, clustering coefficient and motif distribution exist for analysing the structure of networks [1], and each of them captures only one perspective of the properties that are crucial regarding the activity in the network. In this work, we vary the local structure of neuronal networks and observe changes in their activity in silico, i.e. in simulations where the activity of single neurons and their interaction is modeled. The local structure is analysed through the occurrence of different motifs, i.e. different patterns of connectivity. The effect of motifs on network dynamics has been widely studied in different types of networks: from the stability point of view in networks with unspecified dynamics [2], in artificial neural networks [3], and from synchronization point of view in spiking neuronal networks [4]. Our work focuses on noise-driven neuronal networks, where the activity can be characterised by spike trains of neurons in the network, and particularly by the bursting behaviour of the network.

To study the local structure of networks we consider the occurrences of three separate connectivity patterns: (1) the bidirectional edges, (2) the loops of three nodes, and (3) the feed-forward motifs of triples of nodes. Networks with one of these three local connectivity patterns promoted are generated – we abbreviate these networks (L1), (L2) and (L3). In addition, different distance-dependent networks are generated, including networks with ring topology (RT) and biologically plausible topology, obtained by the NETMORPH [5] simulator (NM). All networks except for NM have binomially distributed in-degree, as is the case with the random networks (RN) that are widely used in neuronal activity simulations. Small illustrations of these network structures are shown in Figure ​Figure1.1. Neuronal activity in these types of networks of size N=100 is simulated using the model presented in [6]. The simulations show a difference in the activity of these networks. Preliminary results indicate, that network bursts occur more frequently in distance dependent networks RT and NM, especially in RT. Accordingly, the overall spiking frequency is high in these networks, but also in L3 networks.

Keywords

  • spiking neuronal network, structure, complex networks