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Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children

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Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children. / Roslund, Marja I.; Rantala, Sonja; Puhakka, Riikka; Hui, Nan; Parajuli, Anirudra; Rantalainen, Anna Lea; Sinkkonen, Aki; Grönroos, Mira; Roslund, Marja I.; Soininen, Laura; Yan, Guoyong; Oikarinen, Sami; Laitinen, Olli H.; Hyöty, Heikki; Nurminen, Noora; Kalvo, Raul; Rajaniemi, Juho.

In: Environment International, Vol. 130, 104894, 01.09.2019.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Roslund, MI, Rantala, S, Puhakka, R, Hui, N, Parajuli, A, Rantalainen, AL, Sinkkonen, A, Grönroos, M, Roslund, MI, Soininen, L, Yan, G, Oikarinen, S, Laitinen, OH, Hyöty, H, Nurminen, N, Kalvo, R & Rajaniemi, J 2019, 'Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children' Environment International, vol. 130, 104894. https://doi.org/10.1016/j.envint.2019.06.004

APA

Roslund, M. I., Rantala, S., Puhakka, R., Hui, N., Parajuli, A., Rantalainen, A. L., ... Rajaniemi, J. (2019). Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children. Environment International, 130, [104894]. https://doi.org/10.1016/j.envint.2019.06.004

Vancouver

Roslund MI, Rantala S, Puhakka R, Hui N, Parajuli A, Rantalainen AL et al. Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children. Environment International. 2019 Sep 1;130. 104894. https://doi.org/10.1016/j.envint.2019.06.004

Author

Roslund, Marja I. ; Rantala, Sonja ; Puhakka, Riikka ; Hui, Nan ; Parajuli, Anirudra ; Rantalainen, Anna Lea ; Sinkkonen, Aki ; Grönroos, Mira ; Roslund, Marja I. ; Soininen, Laura ; Yan, Guoyong ; Oikarinen, Sami ; Laitinen, Olli H. ; Hyöty, Heikki ; Nurminen, Noora ; Kalvo, Raul ; Rajaniemi, Juho. / Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children. In: Environment International. 2019 ; Vol. 130.

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@article{3e619440eb664e1391b4f7b85b06c883,
title = "Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children",
abstract = "Polycyclic aromatic hydrocarbons (PAHs) are priority environmental pollutants that cause adverse health effects. PAHs belong to endocrine signaling disruptors to which children are sensitive to. Recent evidence suggests that PAH pollution alters the abundance of environmental bacteria that is associated with health outcomes. The alteration of environmental and commensal microbiota by PAH pollution has never been connected to endocrine signaling pathways. To estimate the risk of endocrine disruption in daycare children, we measured PAHs from soil and air of eleven urban daycare centres in Finland. We analyzed daycare yards' soil and children's gut and skin bacterial communities with 16S rRNA gene metabarcoding and used Kyoto Encyclopaedia of Genes and Genomes database to categorize endocrine signaling pathways. We also assessed the PAH hazard to children's health based on the current risk assesments. We observed associations between signaling pathways in endocrine system and gaseous PAH levels in ambient air. Peroxisome proliferator-activated receptor and adipocytokine signaling pathway decreased with higher chrysene concentration in the air. Soil PAH contamination was associated with altered Actinobacteria, Bacteoridetes and Proteobacteria communities on children's skin and in daycare yard soil. However, adjusted genera were not the same in soil and on skin, with the exception of Mycobacterium that was associated with higher PAH concentrations both in soil and on the skin. Even though fluoranhtene levels were above the current threshold values, total PAHs were below safety threshold values and based on current risk assessments there is a minor risk for child health. Our findings indicate that PAH concentrations that are considered safe may interfere with endocrine signaling by commensal microbiota and alter both environmental and commensal bacterial communities. The imbalance in human microbiota and the decrease in signaling pathways may contribute to emerging public health problems, including inflammatory disorders, obesity and diabetes. Therefore, the optimal risk assessments of PAHs and theoretically also other contaminants shaping commensal microbiota may need to take into account the possibility of the disruption of endocrine signaling pathways.",
author = "Roslund, {Marja I.} and Sonja Rantala and Riikka Puhakka and Nan Hui and Anirudra Parajuli and Rantalainen, {Anna Lea} and Aki Sinkkonen and Mira Gr{\"o}nroos and Roslund, {Marja I.} and Laura Soininen and Guoyong Yan and Sami Oikarinen and Laitinen, {Olli H.} and Heikki Hy{\"o}ty and Noora Nurminen and Raul Kalvo and Juho Rajaniemi",
year = "2019",
month = "9",
day = "1",
doi = "10.1016/j.envint.2019.06.004",
language = "English",
volume = "130",
journal = "Environment International",
issn = "0160-4120",
publisher = "Elsevier",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Endocrine disruption and commensal bacteria alteration associated with gaseous and soil PAH contamination among daycare children

AU - Roslund, Marja I.

AU - Rantala, Sonja

AU - Puhakka, Riikka

AU - Hui, Nan

AU - Parajuli, Anirudra

AU - Rantalainen, Anna Lea

AU - Sinkkonen, Aki

AU - Grönroos, Mira

AU - Roslund, Marja I.

AU - Soininen, Laura

AU - Yan, Guoyong

AU - Oikarinen, Sami

AU - Laitinen, Olli H.

AU - Hyöty, Heikki

AU - Nurminen, Noora

AU - Kalvo, Raul

AU - Rajaniemi, Juho

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Polycyclic aromatic hydrocarbons (PAHs) are priority environmental pollutants that cause adverse health effects. PAHs belong to endocrine signaling disruptors to which children are sensitive to. Recent evidence suggests that PAH pollution alters the abundance of environmental bacteria that is associated with health outcomes. The alteration of environmental and commensal microbiota by PAH pollution has never been connected to endocrine signaling pathways. To estimate the risk of endocrine disruption in daycare children, we measured PAHs from soil and air of eleven urban daycare centres in Finland. We analyzed daycare yards' soil and children's gut and skin bacterial communities with 16S rRNA gene metabarcoding and used Kyoto Encyclopaedia of Genes and Genomes database to categorize endocrine signaling pathways. We also assessed the PAH hazard to children's health based on the current risk assesments. We observed associations between signaling pathways in endocrine system and gaseous PAH levels in ambient air. Peroxisome proliferator-activated receptor and adipocytokine signaling pathway decreased with higher chrysene concentration in the air. Soil PAH contamination was associated with altered Actinobacteria, Bacteoridetes and Proteobacteria communities on children's skin and in daycare yard soil. However, adjusted genera were not the same in soil and on skin, with the exception of Mycobacterium that was associated with higher PAH concentrations both in soil and on the skin. Even though fluoranhtene levels were above the current threshold values, total PAHs were below safety threshold values and based on current risk assessments there is a minor risk for child health. Our findings indicate that PAH concentrations that are considered safe may interfere with endocrine signaling by commensal microbiota and alter both environmental and commensal bacterial communities. The imbalance in human microbiota and the decrease in signaling pathways may contribute to emerging public health problems, including inflammatory disorders, obesity and diabetes. Therefore, the optimal risk assessments of PAHs and theoretically also other contaminants shaping commensal microbiota may need to take into account the possibility of the disruption of endocrine signaling pathways.

AB - Polycyclic aromatic hydrocarbons (PAHs) are priority environmental pollutants that cause adverse health effects. PAHs belong to endocrine signaling disruptors to which children are sensitive to. Recent evidence suggests that PAH pollution alters the abundance of environmental bacteria that is associated with health outcomes. The alteration of environmental and commensal microbiota by PAH pollution has never been connected to endocrine signaling pathways. To estimate the risk of endocrine disruption in daycare children, we measured PAHs from soil and air of eleven urban daycare centres in Finland. We analyzed daycare yards' soil and children's gut and skin bacterial communities with 16S rRNA gene metabarcoding and used Kyoto Encyclopaedia of Genes and Genomes database to categorize endocrine signaling pathways. We also assessed the PAH hazard to children's health based on the current risk assesments. We observed associations between signaling pathways in endocrine system and gaseous PAH levels in ambient air. Peroxisome proliferator-activated receptor and adipocytokine signaling pathway decreased with higher chrysene concentration in the air. Soil PAH contamination was associated with altered Actinobacteria, Bacteoridetes and Proteobacteria communities on children's skin and in daycare yard soil. However, adjusted genera were not the same in soil and on skin, with the exception of Mycobacterium that was associated with higher PAH concentrations both in soil and on the skin. Even though fluoranhtene levels were above the current threshold values, total PAHs were below safety threshold values and based on current risk assessments there is a minor risk for child health. Our findings indicate that PAH concentrations that are considered safe may interfere with endocrine signaling by commensal microbiota and alter both environmental and commensal bacterial communities. The imbalance in human microbiota and the decrease in signaling pathways may contribute to emerging public health problems, including inflammatory disorders, obesity and diabetes. Therefore, the optimal risk assessments of PAHs and theoretically also other contaminants shaping commensal microbiota may need to take into account the possibility of the disruption of endocrine signaling pathways.

U2 - 10.1016/j.envint.2019.06.004

DO - 10.1016/j.envint.2019.06.004

M3 - Article

VL - 130

JO - Environment International

JF - Environment International

SN - 0160-4120

M1 - 104894

ER -