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Evolution of the Seminal O'Hara Rudy Model to More Accurately Simulate the Electrophysiology of Human Ventricular Cardiomyocytes

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review

Details

Original languageEnglish
Title of host publication2019 Computing in Cardiology, CinC 2019
PublisherIEEE Computer Society
ISBN (Electronic)9781728169361
DOIs
Publication statusPublished - 1 Sep 2019
Publication typeA4 Article in a conference publication
Event2019 Computing in Cardiology, CinC 2019 - Singapore, Singapore
Duration: 8 Sep 201911 Sep 2019

Publication series

NameComputing in Cardiology
Volume2019-September
ISSN (Print)2325-8861
ISSN (Electronic)2325-887X

Conference

Conference2019 Computing in Cardiology, CinC 2019
CountrySingapore
CitySingapore
Period8/09/1911/09/19

Abstract

The aim of our work consists in developing a new model of the human ventricular cardiomyocyte, based on the O'Hara-Rudy model (ORd), to improve, in particular, the action potential duration (APD) dependence on the extracellular Ca2+ concentration (Cao). Moreover, the new model reproduces all the available experimental data on APD rate dependence, APD restitution, drug block effects, etc., when the experimental extracellular ionic concentrations are carefully reproduced in simulationsThe main differences between our and the ORd model are: a novel Markovian formulation for the L-type Ca2+ current; the Markovian rapid delayed rectifier K+ current formulation published by Li et al.; a new formulation of the Ca2+ release from the sarcoplasmic reticulum. Several model parameters were modifiedOur BS (Bartolucci-Severi) model successfully improved the ORd, one of the most detailed, used and influent models in computational cardiology, by reproducing the APD-Cao relationship while keeping all the original model features tested in the appropriate experimentally-matched conditions. Furthermore, the BS was suitability as baseline for the generation of in silico populations of models and for reproducing cardiac abnormalities such as early afterdepolarizations.