Tampere University of Technology

TUTCRIS Research Portal

Exploiting Genomic Relations in Big Data Repositories by Graph-Based Search Methods

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)205-210
JournalMachine Learning and Knowledge Extraction
Volume1
Issue number1
Early online date22 Nov 2018
DOIs
Publication statusPublished - 2019
Publication typeA1 Journal article-refereed

Abstract

We are living at a time that allows the generation of mass data in almost any field of science. For instance, in pharmacogenomics, there exist a number of big data repositories, e.g., the Library of Integrated Network-based Cellular Signatures (LINCS) that provide millions of measurements on the genomics level. However, to translate these data into meaningful information, the data need to be analyzable. The first step for such an analysis is the deliberate selection of subsets of raw data for studying dedicated research questions. Unfortunately, this is a non-trivial problem when millions of individual data files are available with an intricate connection structure induced by experimental dependencies. In this paper, we argue for the need to introduce such search capabilities for big genomics data repositories with a specific discussion about LINCS. Specifically, we suggest the introduction of smart interfaces allowing the exploitation of the connections among individual raw data files, giving raise to a network structure, by graph-based searches.

Publication forum classification

Field of science, Statistics Finland