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Extracellular Electrical Stimulation-based in Vitro Neuroscience: A Minireview of Methods and a Paradigm Shift Proposal

Research output: Chapter in Book/Report/Conference proceedingConference contributionScientificpeer-review


Original languageEnglish
Title of host publication2019 26th IEEE International Conference on Electronics, Circuits and Systems (ICECS)
Number of pages4
ISBN (Electronic)978-1-7281-0996-1
ISBN (Print)978-1-7281-0997-8
Publication statusPublished - Nov 2019
Publication typeA4 Article in a conference publication
EventIEEE International Conference on Electronics, Circuits and Systems -
Duration: 31 Dec 1899 → …


ConferenceIEEE International Conference on Electronics, Circuits and Systems
Period31/12/99 → …


Biological neuronal cells communicate using neurochemistry and electrical signals. Electrical stimulation (ES) is utilized to study neuronal cells and networks. Currently, ES is applied and responses observed in an open-loop fashion, which does not resemble natural network I/O. We hypothesize that real-time closed-loop full-duplex (simultaneous two-way) paradigms could provide deeper insight in natural neuronal networks, helping to understand our brains and to control neuronal network states to cure diseases. We present a minireview of ES-based extracellular in vitro neuroscience, our first long-term closed-loop ES experiment results as the proof-of-feasibility of the method, and our paradigm-shifting proposal of dialogical bio-ICT paradigms.


  • bio-ICT interaction, biological neuronal networks, closed-loop control, DSP, electrical stimulation, open-loop control, real-time

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