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Focal Laser Ablation of Prostate Cancer: Numerical Simulation of Temperature and Damage Distribution

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Focal Laser Ablation of Prostate Cancer : Numerical Simulation of Temperature and Damage Distribution. / Marqa, Mohamad Feras; Colin, Pierre; Nevoux, Pierre; Mordon, Serge R.; Betrouni, Nacim.

In: BioMedical Engineering Online, Vol. 10, 45, 02.06.2011.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Marqa, MF, Colin, P, Nevoux, P, Mordon, SR & Betrouni, N 2011, 'Focal Laser Ablation of Prostate Cancer: Numerical Simulation of Temperature and Damage Distribution', BioMedical Engineering Online, vol. 10, 45. https://doi.org/10.1186/1475-925X-10-45

APA

Marqa, M. F., Colin, P., Nevoux, P., Mordon, S. R., & Betrouni, N. (2011). Focal Laser Ablation of Prostate Cancer: Numerical Simulation of Temperature and Damage Distribution. BioMedical Engineering Online, 10, [45]. https://doi.org/10.1186/1475-925X-10-45

Vancouver

Marqa MF, Colin P, Nevoux P, Mordon SR, Betrouni N. Focal Laser Ablation of Prostate Cancer: Numerical Simulation of Temperature and Damage Distribution. BioMedical Engineering Online. 2011 Jun 2;10. 45. https://doi.org/10.1186/1475-925X-10-45

Author

Marqa, Mohamad Feras ; Colin, Pierre ; Nevoux, Pierre ; Mordon, Serge R. ; Betrouni, Nacim. / Focal Laser Ablation of Prostate Cancer : Numerical Simulation of Temperature and Damage Distribution. In: BioMedical Engineering Online. 2011 ; Vol. 10.

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@article{283aee01d56a4ac58259298c48e4e1d9,
title = "Focal Laser Ablation of Prostate Cancer: Numerical Simulation of Temperature and Damage Distribution",
abstract = "Background: The use of minimally invasive ablative techniques in the management of patients with low grade and localized prostate tumours could represent a treatment option between active surveillance and radical therapy. Focal laser ablation (FLA) could be one of these treatment modalities. Dosimetry planning and conformation of the treated area to the tumor remain major issues, especially when, several fibers are required. An effective method to perform pre-treatment planning of this therapy is computer simulation. In this study we present an in vivo validation of a mathematical model.Methods: The simulation model is based on finite elements method (FEM) to solve the bio-heat and the thermal damage equations. Laser irradiation was performed with a 980 nm laser diode system (5 W, 75 s). Light was transmitted using a cylindrical diffusing fiber inserted inside a preclinical animal prostate cancer model induced in Copenhagen rats. Non-enhanced T2-weighted and dynamic gadolinium-enhanced T1-weighted MR imaging examinations were performed at baseline and 48 hours after the procedure. The model was validated by comparing the simulated necrosis volume to the results obtained in vivo on (MRI) and by histological analysis. 3 iso-damage temperatures were considered 43° C, 45° C and 50° C.Results: The mean volume of the tissue necrosis, estimated from the histological analyses was 0.974 ± 0.059 cc and 0.98 ± 0.052 cc on the 48 h MR images. For the simulation model, volumes were: 1.38 cc when T = 43° C, 1.1 cc for T = 45°C and 0.99 cc when T = 50 C°.Conclusions: In this study, a clear correlation was established between simulation and in vivo experiments of FLA for prostate cancer.Simulation is a promising planning technique for this therapy. It needs further more evaluation to allow to FLA to become a widely applied surgical method.",
keywords = "bioheat transfer simulation, Prostate cancerfocal laser ablationthermal damage",
author = "Marqa, {Mohamad Feras} and Pierre Colin and Pierre Nevoux and Mordon, {Serge R.} and Nacim Betrouni",
year = "2011",
month = "6",
day = "2",
doi = "10.1186/1475-925X-10-45",
language = "English",
volume = "10",
journal = "BioMedical Engineering Online",
issn = "1475-925X",
publisher = "Springer Verlag",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Focal Laser Ablation of Prostate Cancer

T2 - Numerical Simulation of Temperature and Damage Distribution

AU - Marqa, Mohamad Feras

AU - Colin, Pierre

AU - Nevoux, Pierre

AU - Mordon, Serge R.

AU - Betrouni, Nacim

PY - 2011/6/2

Y1 - 2011/6/2

N2 - Background: The use of minimally invasive ablative techniques in the management of patients with low grade and localized prostate tumours could represent a treatment option between active surveillance and radical therapy. Focal laser ablation (FLA) could be one of these treatment modalities. Dosimetry planning and conformation of the treated area to the tumor remain major issues, especially when, several fibers are required. An effective method to perform pre-treatment planning of this therapy is computer simulation. In this study we present an in vivo validation of a mathematical model.Methods: The simulation model is based on finite elements method (FEM) to solve the bio-heat and the thermal damage equations. Laser irradiation was performed with a 980 nm laser diode system (5 W, 75 s). Light was transmitted using a cylindrical diffusing fiber inserted inside a preclinical animal prostate cancer model induced in Copenhagen rats. Non-enhanced T2-weighted and dynamic gadolinium-enhanced T1-weighted MR imaging examinations were performed at baseline and 48 hours after the procedure. The model was validated by comparing the simulated necrosis volume to the results obtained in vivo on (MRI) and by histological analysis. 3 iso-damage temperatures were considered 43° C, 45° C and 50° C.Results: The mean volume of the tissue necrosis, estimated from the histological analyses was 0.974 ± 0.059 cc and 0.98 ± 0.052 cc on the 48 h MR images. For the simulation model, volumes were: 1.38 cc when T = 43° C, 1.1 cc for T = 45°C and 0.99 cc when T = 50 C°.Conclusions: In this study, a clear correlation was established between simulation and in vivo experiments of FLA for prostate cancer.Simulation is a promising planning technique for this therapy. It needs further more evaluation to allow to FLA to become a widely applied surgical method.

AB - Background: The use of minimally invasive ablative techniques in the management of patients with low grade and localized prostate tumours could represent a treatment option between active surveillance and radical therapy. Focal laser ablation (FLA) could be one of these treatment modalities. Dosimetry planning and conformation of the treated area to the tumor remain major issues, especially when, several fibers are required. An effective method to perform pre-treatment planning of this therapy is computer simulation. In this study we present an in vivo validation of a mathematical model.Methods: The simulation model is based on finite elements method (FEM) to solve the bio-heat and the thermal damage equations. Laser irradiation was performed with a 980 nm laser diode system (5 W, 75 s). Light was transmitted using a cylindrical diffusing fiber inserted inside a preclinical animal prostate cancer model induced in Copenhagen rats. Non-enhanced T2-weighted and dynamic gadolinium-enhanced T1-weighted MR imaging examinations were performed at baseline and 48 hours after the procedure. The model was validated by comparing the simulated necrosis volume to the results obtained in vivo on (MRI) and by histological analysis. 3 iso-damage temperatures were considered 43° C, 45° C and 50° C.Results: The mean volume of the tissue necrosis, estimated from the histological analyses was 0.974 ± 0.059 cc and 0.98 ± 0.052 cc on the 48 h MR images. For the simulation model, volumes were: 1.38 cc when T = 43° C, 1.1 cc for T = 45°C and 0.99 cc when T = 50 C°.Conclusions: In this study, a clear correlation was established between simulation and in vivo experiments of FLA for prostate cancer.Simulation is a promising planning technique for this therapy. It needs further more evaluation to allow to FLA to become a widely applied surgical method.

KW - bioheat transfer simulation

KW - Prostate cancerfocal laser ablationthermal damage

UR - http://www.scopus.com/inward/record.url?scp=79957840008&partnerID=8YFLogxK

U2 - 10.1186/1475-925X-10-45

DO - 10.1186/1475-925X-10-45

M3 - Article

VL - 10

JO - BioMedical Engineering Online

JF - BioMedical Engineering Online

SN - 1475-925X

M1 - 45

ER -