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FRα: une cible pour la thérapie photodynamique prophylactique des métastases péritonéales ovariennes?

Research output: Contribution to journalReview ArticleScientificpeer-review

Details

Original languageFrench
Pages (from-to)1109-1113
Number of pages5
JournalBULLETIN DU CANCER
Volume101
Issue number12
DOIs
Publication statusPublished - 1 Dec 2014
Publication typeA2 Review article in a scientific journal

Abstract

Partly due to delays in its diagnosis, ovarian cancer's prognosis remains dire after primary therapy. Treatment consists in complete cytoreductive surgery and platinum-based chemotherapy. Recurrence rates are disappointingly high, as 60 % of women with advanced epithelial ovarian cancer considered in remission will develop recurrent disease within five years. Special attention to undetected peritoneal metastasis and residual tumorous cells during surgery is necessary as they are the main predictors of recurrences. Targeted therapies aim to bring chemotherapy, radiotherapy and selective tumor photosensitizer (PS) agents to the targeted cell and its tumoral microenvironment. Folate receptor α (FRα) shows promising prospects in targeting ovarian cancerous cells. Indeed, with good specificity and frequent overexpression in ovarian cancer, FRα is a recurrent topic in recent publications. The aim of this review is to present FRα and the reasons that make it an ideal targeting ligand for ovarian carcinoma therapy. Prophylactic photodynamic therapy (PPDT) using new generation FRα-coupled agents combined with complete cytoreductive surgery could allow for a significant decrease in recurrence rates. Preclinical trials are being run in order to allowfor human clinical applications.

Keywords

  • Folate receptor α, Ovarian cancer, Peritoneal carcinomatosis, Prophylactic photodynamic therapy, Targeted therapy