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From in silico astrocyte cell models to neuron-astrocyte network models: A review

Research output: Contribution to journalReview ArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)76-84
JournalBRAIN RESEARCH BULLETIN
Volume136
Early online date8 Feb 2017
DOIs
Publication statusPublished - 2018
Publication typeA2 Review article in a scientific journal

Abstract

The idea that astrocytes may be active partners in synaptic information processing has recently emerged from abundant experimental reports. Because of their spatial proximity to neurons and their bidirectional communication with them, astrocytes are now considered as an important third element of the synapse. Astrocytes integrate and process synaptic information and by doing so generate cytosolic calcium signals that are believed to reflect neuronal transmitter release. Moreover, they regulate neuronal information transmission by releasing gliotransmitters into the synaptic cleft affecting both pre- and postsynaptic receptors. Concurrent with the first experimental reports of the astrocytic impact on neural network dynamics, computational models describing astrocytic functions have been developed. In this review, we give an overview over the published computational models of astrocytic functions, from single-cell dynamics to the tripartite synapse level and network models of astrocytes and neurons.

ASJC Scopus subject areas

Keywords

  • Astrocyte, In silico, Network, Neuron, Simulation, Tripartite synapse

Publication forum classification

Field of science, Statistics Finland