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From in silico astrocyte cell models to neuron-astrocyte network models: A review

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From in silico astrocyte cell models to neuron-astrocyte network models : A review. / Oschmann, Franziska; Berry, Hugues; Obermayer, Klaus; Lenk, Kerstin.

In: BRAIN RESEARCH BULLETIN, Vol. 136, 2018, p. 76-84.

Research output: Contribution to journalReview ArticleScientificpeer-review

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Oschmann, Franziska ; Berry, Hugues ; Obermayer, Klaus ; Lenk, Kerstin. / From in silico astrocyte cell models to neuron-astrocyte network models : A review. In: BRAIN RESEARCH BULLETIN. 2018 ; Vol. 136. pp. 76-84.

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@article{ff4f646c928f439882453639b18422bf,
title = "From in silico astrocyte cell models to neuron-astrocyte network models: A review",
abstract = "The idea that astrocytes may be active partners in synaptic information processing has recently emerged from abundant experimental reports. Because of their spatial proximity to neurons and their bidirectional communication with them, astrocytes are now considered as an important third element of the synapse. Astrocytes integrate and process synaptic information and by doing so generate cytosolic calcium signals that are believed to reflect neuronal transmitter release. Moreover, they regulate neuronal information transmission by releasing gliotransmitters into the synaptic cleft affecting both pre- and postsynaptic receptors. Concurrent with the first experimental reports of the astrocytic impact on neural network dynamics, computational models describing astrocytic functions have been developed. In this review, we give an overview over the published computational models of astrocytic functions, from single-cell dynamics to the tripartite synapse level and network models of astrocytes and neurons.",
keywords = "Astrocyte, In silico, Network, Neuron, Simulation, Tripartite synapse",
author = "Franziska Oschmann and Hugues Berry and Klaus Obermayer and Kerstin Lenk",
year = "2018",
doi = "10.1016/j.brainresbull.2017.01.027",
language = "English",
volume = "136",
pages = "76--84",
journal = "BRAIN RESEARCH BULLETIN",
issn = "0361-9230",
publisher = "Elsevier",

}

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TY - JOUR

T1 - From in silico astrocyte cell models to neuron-astrocyte network models

T2 - A review

AU - Oschmann, Franziska

AU - Berry, Hugues

AU - Obermayer, Klaus

AU - Lenk, Kerstin

PY - 2018

Y1 - 2018

N2 - The idea that astrocytes may be active partners in synaptic information processing has recently emerged from abundant experimental reports. Because of their spatial proximity to neurons and their bidirectional communication with them, astrocytes are now considered as an important third element of the synapse. Astrocytes integrate and process synaptic information and by doing so generate cytosolic calcium signals that are believed to reflect neuronal transmitter release. Moreover, they regulate neuronal information transmission by releasing gliotransmitters into the synaptic cleft affecting both pre- and postsynaptic receptors. Concurrent with the first experimental reports of the astrocytic impact on neural network dynamics, computational models describing astrocytic functions have been developed. In this review, we give an overview over the published computational models of astrocytic functions, from single-cell dynamics to the tripartite synapse level and network models of astrocytes and neurons.

AB - The idea that astrocytes may be active partners in synaptic information processing has recently emerged from abundant experimental reports. Because of their spatial proximity to neurons and their bidirectional communication with them, astrocytes are now considered as an important third element of the synapse. Astrocytes integrate and process synaptic information and by doing so generate cytosolic calcium signals that are believed to reflect neuronal transmitter release. Moreover, they regulate neuronal information transmission by releasing gliotransmitters into the synaptic cleft affecting both pre- and postsynaptic receptors. Concurrent with the first experimental reports of the astrocytic impact on neural network dynamics, computational models describing astrocytic functions have been developed. In this review, we give an overview over the published computational models of astrocytic functions, from single-cell dynamics to the tripartite synapse level and network models of astrocytes and neurons.

KW - Astrocyte

KW - In silico

KW - Network

KW - Neuron

KW - Simulation

KW - Tripartite synapse

U2 - 10.1016/j.brainresbull.2017.01.027

DO - 10.1016/j.brainresbull.2017.01.027

M3 - Review Article

VL - 136

SP - 76

EP - 84

JO - BRAIN RESEARCH BULLETIN

JF - BRAIN RESEARCH BULLETIN

SN - 0361-9230

ER -