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Genome-wide association study of prostate cancer-specific survival

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Details

Original languageEnglish
Pages (from-to)1796-1800
Number of pages5
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number11
DOIs
Publication statusPublished - 1 Nov 2015
Publication typeA1 Journal article-refereed

Abstract

Background: Unnecessary intervention and overtreatment of indolent disease are common challenges in clinical management of prostate cancer. Improved tools to distinguish lethal from indolent disease are critical. Methods: We performed a genome-wide survival analysis of cause-specific death in 24,023 prostate cancer patients (3,513 disease-specific deaths) from the PRACTICAL and BPC3 consortia. Top findings were assessed for replication in a Norwegian cohort (CONOR). Results: We observed no significant association between genetic variants and prostate cancer survival. Conclusions: Common genetic variants with large impact on prostate cancer survival were not observed in this study. Impact: Future studies should be designed for identification of rare variants with large effect sizes or common variants with small effect sizes.

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