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Genotoxic activity of chlorinated butenoic acids in Salmonella typhimurium strains TA98, TA100 and TA104

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Genotoxic activity of chlorinated butenoic acids in Salmonella typhimurium strains TA98, TA100 and TA104. / Franzén, Robert; Goto, Sumio; Tanabe, Kiyoshi; Morita, Masatoshi.

In: Mutation Research: Genetic Toxicology and Environmental Mutagenesis, Vol. 417, No. 1, 01.09.1998, p. 31-37.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Franzén, R, Goto, S, Tanabe, K & Morita, M 1998, 'Genotoxic activity of chlorinated butenoic acids in Salmonella typhimurium strains TA98, TA100 and TA104', Mutation Research: Genetic Toxicology and Environmental Mutagenesis, vol. 417, no. 1, pp. 31-37. https://doi.org/10.1016/S1383-5718(98)00092-8

APA

Franzén, R., Goto, S., Tanabe, K., & Morita, M. (1998). Genotoxic activity of chlorinated butenoic acids in Salmonella typhimurium strains TA98, TA100 and TA104. Mutation Research: Genetic Toxicology and Environmental Mutagenesis, 417(1), 31-37. https://doi.org/10.1016/S1383-5718(98)00092-8

Vancouver

Franzén R, Goto S, Tanabe K, Morita M. Genotoxic activity of chlorinated butenoic acids in Salmonella typhimurium strains TA98, TA100 and TA104. Mutation Research: Genetic Toxicology and Environmental Mutagenesis. 1998 Sep 1;417(1):31-37. https://doi.org/10.1016/S1383-5718(98)00092-8

Author

Franzén, Robert ; Goto, Sumio ; Tanabe, Kiyoshi ; Morita, Masatoshi. / Genotoxic activity of chlorinated butenoic acids in Salmonella typhimurium strains TA98, TA100 and TA104. In: Mutation Research: Genetic Toxicology and Environmental Mutagenesis. 1998 ; Vol. 417, No. 1. pp. 31-37.

Bibtex - Download

@article{7ea0ca32d66c4df3982edba5917b4f8a,
title = "Genotoxic activity of chlorinated butenoic acids in Salmonella typhimurium strains TA98, TA100 and TA104",
abstract = "The mutagenic activities of several chlorinated butenoic acids, recently identified in chlorinated drinking waters, were determined by the Salmonella microsome assay. The Salmonella typhimurium tester strains TA98, TA100, and TA104 were used without S9 mix. The results from the investigation showed that (Z)-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid (MX, in the open form) was the most potent mutagen of the compounds tested. However, a significant number of mutations was also induced by compounds with structural similarities to MX. In general, all the compounds, except the butenedioic acids, were mutagenic in the assays for both base-pair substitution strains (TA100, TA104) and for the frameshift strain TA98, with the highest mutagenic response observed in strain TA100. When the aldehyde group of MX and of 2-chloro-3-(chloromethyl)-4-oxobutenoic acid (CMCF, in the open form) was replaced by a dichloromethyl group, the mutagenic response in strains TA98 and TA104 changed. We concluded that a frame-shift mutation occurred because of the replacement. The increase of the TA104 mutagenicity suggested that adenosine could be the target for these types of compounds. Further evidence for such possibility were the modified adenosine adducts we could identify for some chlorinated butenoic acids. Copyright (C) 1998 Elsevier Science B.V.",
keywords = "Chlorinated butenoic acid, Mutagenicity test, Salmonella typhimurium strain",
author = "Robert Franz{\'e}n and Sumio Goto and Kiyoshi Tanabe and Masatoshi Morita",
year = "1998",
month = "9",
day = "1",
doi = "10.1016/S1383-5718(98)00092-8",
language = "English",
volume = "417",
pages = "31--37",
journal = "Mutation Research: Genetic Toxicology and Environmental Mutagenesis",
issn = "1383-5718",
publisher = "Elsevier",
number = "1",

}

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TY - JOUR

T1 - Genotoxic activity of chlorinated butenoic acids in Salmonella typhimurium strains TA98, TA100 and TA104

AU - Franzén, Robert

AU - Goto, Sumio

AU - Tanabe, Kiyoshi

AU - Morita, Masatoshi

PY - 1998/9/1

Y1 - 1998/9/1

N2 - The mutagenic activities of several chlorinated butenoic acids, recently identified in chlorinated drinking waters, were determined by the Salmonella microsome assay. The Salmonella typhimurium tester strains TA98, TA100, and TA104 were used without S9 mix. The results from the investigation showed that (Z)-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid (MX, in the open form) was the most potent mutagen of the compounds tested. However, a significant number of mutations was also induced by compounds with structural similarities to MX. In general, all the compounds, except the butenedioic acids, were mutagenic in the assays for both base-pair substitution strains (TA100, TA104) and for the frameshift strain TA98, with the highest mutagenic response observed in strain TA100. When the aldehyde group of MX and of 2-chloro-3-(chloromethyl)-4-oxobutenoic acid (CMCF, in the open form) was replaced by a dichloromethyl group, the mutagenic response in strains TA98 and TA104 changed. We concluded that a frame-shift mutation occurred because of the replacement. The increase of the TA104 mutagenicity suggested that adenosine could be the target for these types of compounds. Further evidence for such possibility were the modified adenosine adducts we could identify for some chlorinated butenoic acids. Copyright (C) 1998 Elsevier Science B.V.

AB - The mutagenic activities of several chlorinated butenoic acids, recently identified in chlorinated drinking waters, were determined by the Salmonella microsome assay. The Salmonella typhimurium tester strains TA98, TA100, and TA104 were used without S9 mix. The results from the investigation showed that (Z)-2-chloro-3-(dichloromethyl)-4-oxobutenoic acid (MX, in the open form) was the most potent mutagen of the compounds tested. However, a significant number of mutations was also induced by compounds with structural similarities to MX. In general, all the compounds, except the butenedioic acids, were mutagenic in the assays for both base-pair substitution strains (TA100, TA104) and for the frameshift strain TA98, with the highest mutagenic response observed in strain TA100. When the aldehyde group of MX and of 2-chloro-3-(chloromethyl)-4-oxobutenoic acid (CMCF, in the open form) was replaced by a dichloromethyl group, the mutagenic response in strains TA98 and TA104 changed. We concluded that a frame-shift mutation occurred because of the replacement. The increase of the TA104 mutagenicity suggested that adenosine could be the target for these types of compounds. Further evidence for such possibility were the modified adenosine adducts we could identify for some chlorinated butenoic acids. Copyright (C) 1998 Elsevier Science B.V.

KW - Chlorinated butenoic acid

KW - Mutagenicity test

KW - Salmonella typhimurium strain

UR - http://www.scopus.com/inward/record.url?scp=0031660926&partnerID=8YFLogxK

U2 - 10.1016/S1383-5718(98)00092-8

DO - 10.1016/S1383-5718(98)00092-8

M3 - Article

VL - 417

SP - 31

EP - 37

JO - Mutation Research: Genetic Toxicology and Environmental Mutagenesis

JF - Mutation Research: Genetic Toxicology and Environmental Mutagenesis

SN - 1383-5718

IS - 1

ER -