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Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer

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Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer. / Rokade, Shalaka S.; Joshi, Komal A.; Mahajan, Ketakee; Patil, Saniya; Tomar, Geetanjali; Dubal, Dnyanesh S.; Parihar, Vijay Singh; Kitture, Rohini; Bellare, Jayesh R.; Ghosh, Sougata.

In: Bioinorganic Chemistry and Applications, Vol. 2018, 4924186, 2018.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Rokade, SS, Joshi, KA, Mahajan, K, Patil, S, Tomar, G, Dubal, DS, Parihar, VS, Kitture, R, Bellare, JR & Ghosh, S 2018, 'Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer', Bioinorganic Chemistry and Applications, vol. 2018, 4924186. https://doi.org/10.1155/2018/4924186

APA

Rokade, S. S., Joshi, K. A., Mahajan, K., Patil, S., Tomar, G., Dubal, D. S., ... Ghosh, S. (2018). Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer. Bioinorganic Chemistry and Applications, 2018, [4924186]. https://doi.org/10.1155/2018/4924186

Vancouver

Rokade SS, Joshi KA, Mahajan K, Patil S, Tomar G, Dubal DS et al. Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer. Bioinorganic Chemistry and Applications. 2018;2018. 4924186. https://doi.org/10.1155/2018/4924186

Author

Rokade, Shalaka S. ; Joshi, Komal A. ; Mahajan, Ketakee ; Patil, Saniya ; Tomar, Geetanjali ; Dubal, Dnyanesh S. ; Parihar, Vijay Singh ; Kitture, Rohini ; Bellare, Jayesh R. ; Ghosh, Sougata. / Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer. In: Bioinorganic Chemistry and Applications. 2018 ; Vol. 2018.

Bibtex - Download

@article{a0394272f9b047b099dfe76504a443c8,
title = "Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer",
abstract = "Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade. Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal plant Gloriosa superba tuber extract (GSTE). The synthesis of the nanoparticles was completed within 5 hours at 100°C which was confirmed by development of dark brown and black colour for PtNPs and PdNPs, respectively, along with enhancement of the peak intensity in the UV-visible spectra. High-resolution transmission electron microscopy (HRTEM) showed that the monodispersed spherical nanoparticles were within a size range below 10 nm. Energy dispersive spectra (EDS) confirmed the elemental composition, while dynamic light scattering (DLS) helped to evaluate the hydrodynamic size of the particles. Anticancer activity against MCF-7 (human breast adenocarcinoma) cell lines was evaluated using MTT assay, flow cytometry, and confocal microscopy. PtNPs and PdNPs showed 49.65 ± 1.99{\%} and 36.26 ± 0.91{\%} of anticancer activity. Induction of apoptosis was most predominant in the underlying mechanism which was rationalized by externalization of phosphatidyl serine and membrane blebbing. These findings support the efficiency of phytogenic fabrication of nanoscale platinum and palladium drugs for management and therapy against breast cancer.",
author = "Rokade, {Shalaka S.} and Joshi, {Komal A.} and Ketakee Mahajan and Saniya Patil and Geetanjali Tomar and Dubal, {Dnyanesh S.} and Parihar, {Vijay Singh} and Rohini Kitture and Bellare, {Jayesh R.} and Sougata Ghosh",
year = "2018",
doi = "10.1155/2018/4924186",
language = "English",
volume = "2018",
journal = "Bioinorganic Chemistry and Applications",
issn = "1565-3633",
publisher = "Hindawi Publishing Corporation",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Gloriosa superba Mediated Synthesis of Platinum and Palladium Nanoparticles for Induction of Apoptosis in Breast Cancer

AU - Rokade, Shalaka S.

AU - Joshi, Komal A.

AU - Mahajan, Ketakee

AU - Patil, Saniya

AU - Tomar, Geetanjali

AU - Dubal, Dnyanesh S.

AU - Parihar, Vijay Singh

AU - Kitture, Rohini

AU - Bellare, Jayesh R.

AU - Ghosh, Sougata

PY - 2018

Y1 - 2018

N2 - Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade. Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal plant Gloriosa superba tuber extract (GSTE). The synthesis of the nanoparticles was completed within 5 hours at 100°C which was confirmed by development of dark brown and black colour for PtNPs and PdNPs, respectively, along with enhancement of the peak intensity in the UV-visible spectra. High-resolution transmission electron microscopy (HRTEM) showed that the monodispersed spherical nanoparticles were within a size range below 10 nm. Energy dispersive spectra (EDS) confirmed the elemental composition, while dynamic light scattering (DLS) helped to evaluate the hydrodynamic size of the particles. Anticancer activity against MCF-7 (human breast adenocarcinoma) cell lines was evaluated using MTT assay, flow cytometry, and confocal microscopy. PtNPs and PdNPs showed 49.65 ± 1.99% and 36.26 ± 0.91% of anticancer activity. Induction of apoptosis was most predominant in the underlying mechanism which was rationalized by externalization of phosphatidyl serine and membrane blebbing. These findings support the efficiency of phytogenic fabrication of nanoscale platinum and palladium drugs for management and therapy against breast cancer.

AB - Green chemistry approaches for designing therapeutically significant nanomedicine have gained considerable attention in the past decade. Herein, we report for the first time on anticancer potential of phytogenic platinum nanoparticles (PtNPs) and palladium nanoparticles (PdNPs) using a medicinal plant Gloriosa superba tuber extract (GSTE). The synthesis of the nanoparticles was completed within 5 hours at 100°C which was confirmed by development of dark brown and black colour for PtNPs and PdNPs, respectively, along with enhancement of the peak intensity in the UV-visible spectra. High-resolution transmission electron microscopy (HRTEM) showed that the monodispersed spherical nanoparticles were within a size range below 10 nm. Energy dispersive spectra (EDS) confirmed the elemental composition, while dynamic light scattering (DLS) helped to evaluate the hydrodynamic size of the particles. Anticancer activity against MCF-7 (human breast adenocarcinoma) cell lines was evaluated using MTT assay, flow cytometry, and confocal microscopy. PtNPs and PdNPs showed 49.65 ± 1.99% and 36.26 ± 0.91% of anticancer activity. Induction of apoptosis was most predominant in the underlying mechanism which was rationalized by externalization of phosphatidyl serine and membrane blebbing. These findings support the efficiency of phytogenic fabrication of nanoscale platinum and palladium drugs for management and therapy against breast cancer.

U2 - 10.1155/2018/4924186

DO - 10.1155/2018/4924186

M3 - Article

VL - 2018

JO - Bioinorganic Chemistry and Applications

JF - Bioinorganic Chemistry and Applications

SN - 1565-3633

M1 - 4924186

ER -