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Glycerol mediated synthesis of 5-substituted 1H-tetrazole under catalyst free conditions

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Original languageEnglish
Pages (from-to)161-164
Number of pages4
JournalChinese Chemical Letters
Issue number2
Publication statusPublished - Feb 2012
Externally publishedYes
Publication typeA1 Journal article-refereed


We have developed simple, cost effective and environmentally benign protocol for the synthesis of 5-substituted 1H-tetrazoles via [2,3] cycloaddition reaction from organic nitriles and sodium azide in glycerol under catalyst free condition. The corresponding 5-substituted 1H-tetrazoles were obtained with good to excellent yields (68-95%).

ASJC Scopus subject areas


  • 5-Substituted 1H-tetrazole, [3+2] Cycloaddition, Catalyst free, Glycerol, Nitriles