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Guanidinium cations pair with positively charged arginine side chains in water

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Original languageEnglish
Pages (from-to)1387-1389
Number of pages3
JournalJournal of Physical Chemistry Letters
Issue number12
Publication statusPublished - 16 Jun 2011
Publication typeA1 Journal article-refereed


Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.

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