Guanidinium cations pair with positively charged arginine side chains in water
Research output: Contribution to journal › Article › Scientific › peer-review
|Number of pages||3|
|Journal||Journal of Physical Chemistry Letters|
|Publication status||Published - 16 Jun 2011|
|Publication type||A1 Journal article-refereed|
Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.