Tampere University of Technology

TUTCRIS Research Portal

Guanidinium cations pair with positively charged arginine side chains in water

Research output: Contribution to journalArticleScientificpeer-review

Details

Original languageEnglish
Pages (from-to)1387-1389
Number of pages3
JournalJournal of Physical Chemistry Letters
Volume2
Issue number12
DOIs
Publication statusPublished - 16 Jun 2011
Publication typeA1 Journal article-refereed

Abstract

Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.

ASJC Scopus subject areas