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Guanidinium cations pair with positively charged arginine side chains in water

Research output: Contribution to journalArticleScientificpeer-review

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Guanidinium cations pair with positively charged arginine side chains in water. / Kubíčková, Anna; Křížek, Tomáš; Coufal, Pavel; Wernersson, Erik; Heyda, Jan; Jungwirth, Pavel.

In: Journal of Physical Chemistry Letters, Vol. 2, No. 12, 16.06.2011, p. 1387-1389.

Research output: Contribution to journalArticleScientificpeer-review

Harvard

Kubíčková, A, Křížek, T, Coufal, P, Wernersson, E, Heyda, J & Jungwirth, P 2011, 'Guanidinium cations pair with positively charged arginine side chains in water', Journal of Physical Chemistry Letters, vol. 2, no. 12, pp. 1387-1389. https://doi.org/10.1021/jz2005495

APA

Kubíčková, A., Křížek, T., Coufal, P., Wernersson, E., Heyda, J., & Jungwirth, P. (2011). Guanidinium cations pair with positively charged arginine side chains in water. Journal of Physical Chemistry Letters, 2(12), 1387-1389. https://doi.org/10.1021/jz2005495

Vancouver

Kubíčková A, Křížek T, Coufal P, Wernersson E, Heyda J, Jungwirth P. Guanidinium cations pair with positively charged arginine side chains in water. Journal of Physical Chemistry Letters. 2011 Jun 16;2(12):1387-1389. https://doi.org/10.1021/jz2005495

Author

Kubíčková, Anna ; Křížek, Tomáš ; Coufal, Pavel ; Wernersson, Erik ; Heyda, Jan ; Jungwirth, Pavel. / Guanidinium cations pair with positively charged arginine side chains in water. In: Journal of Physical Chemistry Letters. 2011 ; Vol. 2, No. 12. pp. 1387-1389.

Bibtex - Download

@article{f3d81a9cfed44935a26ab95a1e03793b,
title = "Guanidinium cations pair with positively charged arginine side chains in water",
abstract = "Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.",
author = "Anna Kub{\'i}čkov{\'a} and Tom{\'a}š Kř{\'i}žek and Pavel Coufal and Erik Wernersson and Jan Heyda and Pavel Jungwirth",
year = "2011",
month = "6",
day = "16",
doi = "10.1021/jz2005495",
language = "English",
volume = "2",
pages = "1387--1389",
journal = "Journal of Physical Chemistry Letters",
issn = "1948-7185",
publisher = "American Chemical Society",
number = "12",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Guanidinium cations pair with positively charged arginine side chains in water

AU - Kubíčková, Anna

AU - Křížek, Tomáš

AU - Coufal, Pavel

AU - Wernersson, Erik

AU - Heyda, Jan

AU - Jungwirth, Pavel

PY - 2011/6/16

Y1 - 2011/6/16

N2 - Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.

AB - Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.

UR - http://www.scopus.com/inward/record.url?scp=79959413305&partnerID=8YFLogxK

U2 - 10.1021/jz2005495

DO - 10.1021/jz2005495

M3 - Article

VL - 2

SP - 1387

EP - 1389

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

SN - 1948-7185

IS - 12

ER -