Guanidinium cations pair with positively charged arginine side chains in water
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Guanidinium cations pair with positively charged arginine side chains in water. / Kubíčková, Anna; Křížek, Tomáš; Coufal, Pavel; Wernersson, Erik; Heyda, Jan; Jungwirth, Pavel.
In: Journal of Physical Chemistry Letters, Vol. 2, No. 12, 16.06.2011, p. 1387-1389.Research output: Contribution to journal › Article › Scientific › peer-review
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TY - JOUR
T1 - Guanidinium cations pair with positively charged arginine side chains in water
AU - Kubíčková, Anna
AU - Křížek, Tomáš
AU - Coufal, Pavel
AU - Wernersson, Erik
AU - Heyda, Jan
AU - Jungwirth, Pavel
PY - 2011/6/16
Y1 - 2011/6/16
N2 - Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.
AB - Using capillary electrophoresis and molecular dynamics simulations, we directly demonstrate that guanidinium cations exhibit an affinity for the positively charged side chains of arginine-containing peptides in aqueous solutions, while no such effect is observed for sodium cations and/or lysine. Such a counterintuitive pairing between these two positively charged moieties has implications for destabilization and aggregation of arginine-rich proteins in guanidinium salt solutions.
UR - http://www.scopus.com/inward/record.url?scp=79959413305&partnerID=8YFLogxK
U2 - 10.1021/jz2005495
DO - 10.1021/jz2005495
M3 - Article
VL - 2
SP - 1387
EP - 1389
JO - Journal of Physical Chemistry Letters
JF - Journal of Physical Chemistry Letters
SN - 1948-7185
IS - 12
ER -